| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PICK1 |
| Specificity: |
This antibody reacts specifically with PICK1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PICK1 |
| Gene ID: |
9463 |
| Swiss Prot: |
Q9NRD5 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Involved in regulation of astrocyte morphology, Involved in the clustering of various receptors, May be regulated upon PRKCA activation, May regulate ASIC1/ASIC3 channel, Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors, Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex, Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD), antagonistic to Arp2/3 complex activator WASL/N-WASP function, possibly by acting at the receptor internalization level, the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis, Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
dJ1039K5 MGC15204 |
| Also known as: |
PICK1 Polyclonal Antibody |
| Other name: |
Anti-PICK1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PICK1 |
| Short name: |
Anti-PICK1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-protein interacting including PRKCA 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Arp2/3 complex binding, Cell surfaces, PICK and PRKCABP, PICK1 and IDBG-7244 and ENSG00000100151 and 9463, PRKCABP and IDBG-641553 and ENSBTAG00000015268 and 533737, Pick1 and IDBG-161096 and ENSMUSG00000068206 and 102632642, this GO :0002092 and positive regulation of receptor internalization and biological process this GO :0005080 and protein kinase C binding and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006605 and protein targeting and biological process this GO :0006890 and retrograde vesicle-mediated transport, this GO :0005080 : protein kinase C binding, this GO :0005080 : protein kinase C binding and also this GO :0005102 : receptor binding and also this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016887 : ATPase activity and also this GO :0019899 : enzyme binding and also this GO :0019904 : protein domain specific binding and also this GO :0046872 : metal ion binding and also this GO :0051015 : actin filament binding and also this GO :0071933 : Arp2/3 complex binding, this GO :0005102 : receptor binding, this GO :0005515 : protein binding, this GO :0008022 : protein C-terminus binding, this GO :0016887 : ATPase activity, this GO :0019899 : enzyme binding, this GO :0019904 : protein domain specific binding, this GO :0046872 : metal ion binding, this GO :0051015 : actin filament binding, this GO :0071933 : Arp2/3 complex binding, this GO lgi to ER and biological process this GO :0007205 and protein kinase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007268 and synaptic transmission and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0014069 and postsynaptic density and cellular component this GO :0015844 and monoamine transport and biological process this GO :0016887 and ATPase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0021782 and glial cell development and biological process this GO :0030054 and cell junction and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0034316 and negative regulation of Arp2/3 complex-mediated actin nucleation and biological process this GO :0036294 and cellular response to decreased oxygen levels and biological process this GO :0042149 and cellular response to glucose starvation and biological process this GO :0042734 and presynaptic membrane and cellular component this GO :0043005 and neuron projection and cellular component this GO :0043045 and DNA methylation involved in embryo development and biological process this GO :0043046 and DNA methylation involved in gamete generation and biological process this GO :0043113 and receptor clustering and biological process this GO :0045161 and neuronal ion channel clustering and biological process this GO :0045202 and synapse and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0046872 and metal ion binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051015 and actin filament binding and molecular function this GO :0060292 and long term synaptic depression and biological process this GO :0071933 and Arp2/3 complex binding and molecular function this GO :0097061 and dendritic spine organization and biological process this GO :0097062 and dendritic spine maintenance and biological process this GO :0097481 and neuronal postsynaptic density and cellular component, 18693, protein interacting with PRKCA 1 |
| Identity: |
9394 |
| Gene: |
PICK1 |
More about : PICK1 |
| Long gene name: |
protein interacting with PRKCA 1 |
| Synonyms gene: |
PRKCABP |
| Synonyms gene name: |
alpha binding protein protein interacting with PRKCA , protein kinase C |
| Locus: |
22q13, 1 |
| Discovery year: |
1999-10-19 |
| GenBank acession: |
AL049654 |
| Entrez gene record: |
9463 |
| Pubmed identfication: |
10340301 10591208 |
| RefSeq identity: |
NM_012407 |
| Classification: |
PDZ domain containing Classical BAR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000151159 |