| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SUZ12 |
| Specificity: |
This antibody reacts specifically with SUZ12 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SUZ12/CHET9 |
| Gene ID: |
23512 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CBX4, CBX8, EZH2, PHC2, PHC3, PcG proteins act by forming multiprotein complexes, PcG proteins are not required to initiate repression, RBBP4 and RBBP7, RING1 and RNF2, SCMH1, SUZ12 is a component of the PRC2 complex, SUZ12 is a component of the PRC2 complex, SUZ12 mRNA is upregulated in a number of tumors including breast and colon, SUZ12/JJAZ1, They probably act via the methylation of histones, This complex is distinct from the PRC1 complex, but to maintain it during later stages of development, composed of EED, rendering chromatin heritably changed in its expressibility, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, which contains many other PcG proteins like BMI1, which methylates Lys-9 and Lys-27 residues of histone H3, UZ12 is a polycomb group (PcG) protein |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
JJAZ1 KIAA0160 CHET9 |
| Also known as: |
SUZ12 Polyclonal Antibody |
| Other name: |
Anti-SUZ12 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SUZ12 |
| Short name: |
Anti-SUZ12 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SUZ12 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17101 |
| Gene: |
SUZ12 |
More about : SUZ12 |
| Long gene name: |
SUZ12 polycomb repressive complex 2 subunit |
| Synonyms gene name: |
suppressor of zeste 12 homolog (Drosophila) |
| Locus: |
17q11, 2 |
| Discovery year: |
2004-12-14 |
| GenBank acession: |
D63881 |
| Entrez gene record: |
23512 |
| Pubmed identfication: |
8590280 11371647 18784248 |
| RefSeq identity: |
NM_015355 |
| Classification: |
Polycomb repressive complex 2 Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000132813 |