| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HAX1 |
| Specificity: |
This antibody reacts specifically with HAX1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HAX1 |
| Gene ID: |
10456 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease, HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, It is also known to associate with PKD2 (involved in polycystic kidney disease) and with cortactin/EMS1, It may also function in promoting cell survival, binding to its N-terminal region, so may play a role in mRNA stability and transport, RelevanceHAX1 associates with HS1 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HS1BP1 HCLSBP1 |
| Also known as: |
HAX1 Polyclonal Antibody |
| Other name: |
Anti-HAX1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HAX1 |
| Short name: |
Anti-HAX1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HCLS1 associated protein X-1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
HAX1 and IDBG-102924 and ENSG00000143575 and 10456, HAX1 and IDBG-632533 and ENSBTAG00000013025 and 506895, HCLSBP1 and HS1BP1 and SCN3, Hax1 and IDBG-165357 and ENSMUSG00000027944 and 23897, nuclei, protein N-terminus binding, this GO :0005515 and protein binding and molecular function this GO :0005635 and nuclear envelope and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016529 and sarcoplasmic reticulum and cellular component this GO :0019904 and protein domain specific binding and molecular function this GO :0019966 and interleukin-1 binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030136 and clathrin-coated vesicle and cellular component this GO :0030833 and regulation of actin filament polymerization and biological process this GO :0030854 and positive regulation of granulocyte differentiation and biological process this GO :0031965 and nuclear membrane and cellular component this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process this GO :2000251 and positive regulation of actin cytoskeleton reorganization and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0019904 : protein domain specific binding and also this GO :0019966 : interleukin-1 binding and also this GO :0047485 : protein N-terminus binding, this GO :0019904 : protein domain specific binding, this GO :0019966 : interleukin-1 binding, this GO :0047485 : protein N-terminus binding, HCLS1 associated protein X-1 |
| Identity: |
16915 |
| Gene: |
HAX1 |
More about : HAX1 |
| Long gene name: |
HCLS1 associated protein X-1 |
| Synonyms name: |
HCLS1 (and PKD2) associated protein |
| Locus: |
1q21, 3 |
| Discovery year: |
2005-05-19 |
| GenBank acession: |
U68566 |
| Entrez gene record: |
10456 |
| Pubmed identfication: |
9058808 10760273 |
| RefSeq identity: |
NM_006118 |
| Havana BLAST/BLAT: |
OTTHUMG00000035978 |
| Locus Specific Databases: |
HAX1base: Mutation registry for severe congenital neutropenia (Kostmann disease) LRG_64 |