| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Galactosidase alpha |
| Specificity: |
This antibody reacts specifically with Galactosidase alpha |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Lysosome |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Galactosidase alpha |
| Gene ID: |
2717 |
| Swiss Prot: |
P06280 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk, Death results from renal failure, Defects in GLA are the cause of Fabry's disease (FD), FD is a rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues, Heterozygous females may exhibit the disorder in an attenuated form, Patients may show ocular deposits, and burning pain in the extremities, cardiac or cerebral complications of hypertension or other vascular disease, febrile episodes, galactomannans and galactohydrolase, including galactose oligosaccharides, non reducing alpha D galactose residues in alpha D galactosides, they are more likely to show corneal opacities, Galactosidase alpha is involved in the hydrolysis of terminal |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GALA |
| Also known as: |
Galactosidase alpha Polyclonal Antibody |
| Other name: |
Anti-Galactosidase alpha Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Galactosidase alpha |
| Short name: |
Anti-Galactosidase alpha (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Galactosidase a (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4296 |
| Gene: |
GLA |
More about : GLA |
| Long gene name: |
galactosidase alpha |
| Locus: |
Xq22, 1 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X16889 |
| Entrez gene record: |
2717 |
| Havana BLAST/BLAT: |
OTTHUMG00000022026 |
| Locus Specific Databases: |
Mental Retardation database LRG_672 |