| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TYRO3 |
| Specificity: |
This antibody reacts specifically with TYRO3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Tyrosine-protein kinase receptor TYRO3 |
| Gene ID: |
7301 |
| Swiss Prot: |
Q06418 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activates the AKT survival pathway, Following activation by ligand, Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules, Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, Regulates many physiological processes including cell survival, TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes, interacts with PIK3R1 and thereby enhances PI3-kinase activity, migration and differentiation, platelet aggregation and cytoskeleton reorganization, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Dtk Brt Tif Sky Etk-2 Rek |
| Also known as: |
TYRO3 Polyclonal Antibody |
| Other name: |
Anti-TYRO3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TYRO3 |
| Short name: |
Anti-TYRO3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TYRO3 protein tyrosine kinase (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BYK and Dtk and RSE and Sky and Tif, TYRO3 and IDBG-646302 and ENSBTAG00000001694 and 788224, TYRO3 and IDBG-7206 and ENSG00000092445 and 7301, Tyro3 and IDBG-199993 and ENSMUSG00000027298 and 22174, nuclei, this GO :0001779 and natural killer cell differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004716 and receptor signaling protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005635 and nuclear envelope and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007283 and spermatogenesis and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004716 : receptor signaling protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004716 : receptor signaling protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0046982 : protein heterodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0046982 : protein heterodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0021885 and forebrain cell migration and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030168 and platelet activation and biological process this GO :0032940 and secretion by cell and biological process this GO :0034122 and negative regulation of toll-like receptor signaling pathway and biological process this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0042698 and ovulation cycle and biological process this GO :0043277 and apoptotic cell clearance and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045824 and negative regulation of innate immune response and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0051250 and negative regulation of lymphocyte activation and biological process this GO :0060068 and vagina development and biological process this GO :0070050 and neuron cellular homeostasis and biological process this GO :0070527 and platelet aggregation and biological process, TYRO3 protein tyrosine kinase |
| Identity: |
12446 |
| Gene: |
TYRO3 |
More about : TYRO3 |
| Long gene name: |
TYRO3 protein tyrosine kinase |
| Synonyms gene: |
RSE |
| Locus: |
15q15, 1 |
| Discovery year: |
1992-10-02 |
| GenBank acession: |
D50479 |
| Entrez gene record: |
7301 |
| Pubmed identfication: |
7851890 |
| Classification: |
Fibronectin type III domain containing I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000130341 |