| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
AQP0 |
| Specificity: |
This antibody reacts specifically with AQP0 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human AQP0 |
| Gene ID: |
4284 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Aquaporin 0 or MIP26 (major intrinsic protein 26kD), Aquaporin families of proteins are predicted to contain six transmembrane domains, Defects in Aquaporin 0 are a cause of autosomal recessive congenital cataract, Human Aquaporin 0 is a 263 amino acid transmembrane protein belonging to the MIP family, Interestingly, Mammalian red cells, The N and C terminus are predicted to be cytoplasmic, The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane, The lens specific Aquaporin 0 represents up to 80% of total lens membrane protein, Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein aquaporins, and Aquaporin 1 has been the foundation of the growing family of aquaporins, and descending thin limb of Henle are extraordinarily permeable to water, renal proximal tubules, tissue membranes show a great degree of water permeability, Water is a critical component of all living cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MP26 LIM1 AQP0 |
| Also known as: |
AQP0 Polyclonal Antibody |
| Other name: |
Anti-AQP0 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
AQP0 |
| Short name: |
Anti-AQP0 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-AQP0 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7103 |
| Gene: |
MIP |
More about : MIP |
| Long gene name: |
major intrinsic protein of lens fiber |
| Synonyms name: |
aquaporin 0 |
| Locus: |
12q13 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
4284 |
| Pubmed identfication: |
1840563 7536742 |
| RefSeq identity: |
NM_012064 |
| Classification: |
Aquaporins |
| Havana BLAST/BLAT: |
OTTHUMG00000170571 |