| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BMPR1B |
| Specificity: |
This antibody reacts specifically with BMPR1B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BMPR1B |
| Gene ID: |
658 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A to E, Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo, BDA2 was described first in a large Norwegian kindred, Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals, Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA), Receptor for BMP7/OP-1 and GDF5, The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers), They have been classified on an anatomic and genetic basis into five groups, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, and hand/foot malformations, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits, then bind and activate SMAD transcriptional regulators, very short limbs, Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600], Involvement in disease, On ligand binding |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALK6 CDw293 |
| Also known as: |
BMPR1B Polyclonal Antibody |
| Other name: |
Anti-BMPR1B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BMPR1B |
| Short name: |
Anti-BMPR1B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, classification IB (polyclonal), antibody to-bone morphogenetic protein receptor |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ALK-6 and ALK6 and CDw293, BMPR1B and IDBG-30667 and ENSG00000138696 and 658, BMPR1B and IDBG-641011 and ENSBTAG00000002081 and 407128, Bmpr1b and IDBG-196928 and ENSMUSG00000052430 and 12167, Plasma membranes, this GO :0001501 and skeletal system development and biological process this GO :0001502 and cartilage condensation and biological process this GO :0001550 and ovarian cumulus expansion and biological process this GO :0001654 and eye development and biological process this GO :0002062 and chondrocyte differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005025 and transforming growth factor beta receptor activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005025 : transforming growth factor beta receptor activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005025 : transforming growth factor beta receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030154 and cell differentiation and biological process this GO :0030501 and positive regulation of bone mineralization and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0031290 and retinal ganglion cell axon guidance and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0042698 and ovulation cycle and biological process this GO :0043010 and camera-type eye development and biological process this GO :0043235 and receptor complex and cellular component this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0060041 and retina development in camera-type eye and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, transforming growth factor beta receptor activity, type I, type I and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, type I and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, type IB, bone morphogenetic protein receptor |
| Identity: |
1077 |
| Gene: |
BMPR1B |
More about : BMPR1B |
| Long gene name: |
bone morphogenetic protein receptor type 1B |
| Synonyms gene name: |
bone morphogenetic protein receptor, type IB |
| Locus: |
4q22, 3 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
D89675 |
| Entrez gene record: |
658 |
| Pubmed identfication: |
8140412 9730621 |
| RefSeq identity: |
NM_001203 |
| Classification: |
Type 1 receptor serine/threonine kinases CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000130991 |