| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ALOX15B |
| Specificity: |
This antibody reacts specifically with ALOX15B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ALOX15B/15 Lipoxygenase 2 |
| Gene ID: |
247 |
| Swiss Prot: |
O15296 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE, Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE, Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S, May also regulate cytokine secretion by macrophages and therefore play a role in the immune response, May also regulate macrophage differentiation into proatherogenic foam cells, May regulate progression through the cell cycle and cell proliferation, 15S)-diHPETE, Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
15-LOX-2 |
| Also known as: |
ALOX15B Polyclonal Antibody |
| Other name: |
Anti-ALOX15B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ALOX15B |
| Short name: |
Anti-ALOX15B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, classification B (polyclonal), antibody to-arachidonate 15-lipoxygenase |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
15-LOX-2, ALOX15B and IDBG-27642 and ENSG00000179593 and 247, ALOX15B and IDBG-635491 and ENSBTAG00000008779 and 286820, Alox8 and IDBG-190116 and ENSMUSG00000020891 and 11688, acting on single donors with incorporation of molecular oxygen, acting on single donors with incorporation of molecular oxygen, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, incorporation of two atoms of oxygen and also this GO :0036403 : arachidonate 8(S)-lipoxygenase activity and also this GO :0046872 : metal ion binding and also this GO :0050473 : arachidonate 15-lipoxygenase activity, incorporation of two atoms of oxygen and molecular function this GO :0019369 and arachidonic acid metabolic process and biological process this GO :0019372 and lipoxygenase pathway and biological process this GO :0019898 and extrinsic component of membrane and cellular component this GO :0030336 and negative regulation of cell migration and biological process this GO :0030850 and prostate gland development and biological process this GO :0030856 and regulation of epithelial cell differentiation and biological process this GO :0035360 and positive regulation of peroxisome proliferator activated receptor signaling pathway and biological process this GO :0036403 and arachidonate 8(S)-lipoxygenase activity and molecular function this GO :0043651 and linoleic acid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045618 and positive regulation of keratinocyte differentiation and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045926 and negative regulation of growth and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050473 and arachidonate 15-lipoxygenase activity and molecular function this GO :0051122 and hepoxilin biosynthetic process and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0090197 and positive regulation of chemokine secretion and biological process, nuclei, oxidoreductase activity, this GO :0005506 and iron ion binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006629 and lipid metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008289 and lipid binding and molecular function this GO :0010744 and positive regulation of macrophage derived foam cell differentiation and biological process this GO :0016020 and membrane and cellular component this GO :0016165 and lipoxygenase activity and molecular function this GO :0016702 and oxidoreductase activity, this GO :0005506 : iron ion binding, this GO :0005506 : iron ion binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0008289 : lipid binding and also this GO :0016165 : lipoxygenase activity and also this GO :0016702 : oxidoreductase activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0008289 : lipid binding, this GO :0016165 : lipoxygenase activity, this GO :0016702 : oxidoreductase activity, this GO :0036403 : arachidonate 8(S)-lipoxygenase activity, this GO :0046872 : metal ion binding, this GO :0050473 : arachidonate 15-lipoxygenase activity, type B, arachidonate 15-lipoxygenase |
| Identity: |
434 |
| Gene: |
ALOX15B |
More about : ALOX15B |
| Long gene name: |
arachidonate 15-lipoxygenase, type B |
| Synonyms gene name: |
arachidonate 15-lipoxygenase, second type |
| Locus: |
17p13, 1 |
| Discovery year: |
1998-07-22 |
| GenBank acession: |
U78294 |
| Entrez gene record: |
247 |
| Pubmed identfication: |
9177185 |
| Classification: |
Arachidonate lipoxygenases |
| Havana BLAST/BLAT: |
OTTHUMG00000108181 |