| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TTBK1 |
| Specificity: |
This antibody reacts specifically with TTBK1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TTBK1/BDTK |
| Gene ID: |
84630 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, Phosphorylation of Tau causes its aggregation and subsequent loss of function, Specifically, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, TTBK1 uses divalent cations, Two isoforms of TTBK1 are expressed due to alternative splicing events, also known as BDTK (brain-derived tau kinase), creating a phosphoprotein and ADP, is a 1, such as magnesium and manganese, suggesting an important role for TTBK1 in the control of tubulin dynamics, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, tyrosine and serine residues, 321 amino acid protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family, TTBK1 (tau tubulin kinase 1) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1855 |
| Also known as: |
TTBK1 Polyclonal Antibody |
| Other name: |
Anti-TTBK1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TTBK1 |
| Short name: |
Anti-TTBK1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TTBK1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
19140 |
| Gene: |
TTBK1 |
More about : TTBK1 |
| Long gene name: |
tau tubulin kinase 1 |
| Locus: |
6p21, 1 |
| Discovery year: |
2003-05-28 |
| GenBank acession: |
AB058758 |
| Entrez gene record: |
84630 |
| Pubmed identfication: |
11347906 |
| Havana BLAST/BLAT: |
OTTHUMG00000014725 |