| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HRG beta 1 |
| Specificity: |
This antibody reacts specifically with HRG beta 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human NRG1 |
| Gene ID: |
3084 |
| Swiss Prot: |
Q02297 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Concomitantly recruits ERBB1 and ERBB2 coreceptors, Isoform 10 may play a role in motor and sensory neuron development, The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, and skeletal muscle cells, glial, implication in the development of the myocardium such as trabeculation of the developing heart, inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction, neuronal, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, stimulating Schwann cell proliferation, stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells, Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HRGP HPRG |
| Also known as: |
HRG beta 1 Polyclonal Antibody |
| Other name: |
Anti-HRG beta 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HRG beta 1 |
| Short name: |
Anti-HRG beta 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-histidine-rich glycoprotein b 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Extracellular, HPRG and HRGP and THPH11, HRG and IDBG-634671 and ENSBTAG00000001265 and 101909599, HRG and IDBG-69039 and ENSG00000113905 and 3273, Hrg and IDBG-148872 and ENSMUSG00000022877 and 94175, metal ion binding, this GO :0001525 and angiogenesis and biological process this GO :0002576 and platelet degranulation and biological process this GO :0002839 and positive regulation of immune response to tumor cell and biological process this GO :0004867 and serine-type endopeptidase inhibitor activity and molecular function this GO :0004869 and cysteine-type endopeptidase inhibitor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007596 and blood coagulation and biological process this GO :0008201 and heparin binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010543 and regulation of platelet activation and biological process this GO :0010593 and negative regulation of lamellipodium assembly and biological process this GO :0010951 and negative regulation of endopeptidase activity and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0015886 and heme transport and biological process this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019865 and immunoglobulin binding and molecular function this GO :0020037 and heme binding and molecular function this GO :0030168 and platelet activation and biological process this GO :0030193 and regulation of blood coagulation and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0031093 and platelet alpha granule lumen and cellular component this GO :0031982 and vesicle and cellular component this GO :0032956 and regulation of actin cytoskeleton organization and biological process this GO :0033629 and negative regulation of cell adhesion mediated by integrin and biological process this GO :0034395 and regulation of transcription from RNA polymerase II promoter in response to iron and biological process this GO :0036019 and endolysosome and cellular component this GO :0042730 and fibrinolysis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043254 and regulation of protein complex assembly and biological process this GO :0043395 and heparan sulfate proteoglycan binding and molecular function this GO :0043537 and negative regulation of blood vessel endothelial cell migration and biological process this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050730 and regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050832 and defense response to fungus and biological process this GO :0051894 and positive regulation of focal adhesion assembly and biological process this GO :0051918 and negative regulation of fibrinolysis and biological process this GO :0061474 and pha this GO lysosome membrane and cellular component this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0072562 and blood microparticle and cellular component this GO :0097037 and heme export and biological process this GO :1900747 and negative regulation of vascular endothelial growth factor signaling pathway and biological process this GO :2000504 and positive regulation of blood vessel remodeling and biological process this GO :2001027 and negative regulation of endothelial cell chemotaxis and biological process, this GO :0004867 : serine-type endopeptidase inhibitor activity, this GO :0004867 : serine-type endopeptidase inhibitor activity and also this GO :0004869 : cysteine-type endopeptidase inhibitor activity and also this GO :0005102 : receptor binding and also this GO :0005515 : protein binding and also this GO :0008201 : heparin binding and also this GO :0008270 : zinc ion binding and also this GO :0019865 : immunoglobulin binding and also this GO :0020037 : heme binding and also this GO :0043395 : heparan sulfate proteoglycan binding and also this GO :0046872 : metal ion binding, this GO :0004869 : cysteine-type endopeptidase inhibitor activity, this GO :0005102 : receptor binding, this GO :0005515 : protein binding, this GO :0008201 : heparin binding, this GO :0008270 : zinc ion binding, this GO :0019865 : immunoglobulin binding, this GO :0020037 : heme binding, this GO :0043395 : heparan sulfate proteoglycan binding, this GO :0046872 : metal ion binding, 280820, histidine-rich glycoprotein |
| Identity: |
5181 |
| Gene: |
HRG |
More about : HRG |
| Long gene name: |
histidine rich glycoprotein |
| Synonyms gene name: |
histidine-rich glycoprotein |
| Synonyms name: |
histidine-proline rich glycoprotein thrombophilia due to elevated HRG |
| Locus: |
3q27, 3 |
| Discovery year: |
1989-05-25 |
| Entrez gene record: |
3273 |
| Pubmed identfication: |
1678514 |
| RefSeq identity: |
NM_000412 |
| Classification: |
Cystatins, type 4 |
| Havana BLAST/BLAT: |
OTTHUMG00000156578 |
| Locus Specific Databases: |
LRG_601 |