| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SIRT7 |
| Specificity: |
This antibody reacts specifically with SIRT7 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SIRT7 |
| Gene ID: |
51547 |
| Swiss Prot: |
Q9NRC8 |
| Applications: |
IF(IHC-F), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells, H3K18Ac, H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors, In contrast to other histone deacetylases, May also deacetylate p53/TP53 and promotes cell survival, Moreover, SIRT7 thereby acts as a transcription repressor, Stimulates transcription activity of the RNA polymerase I complex, These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions, directly linked to control of gene expression, displays selectivity for a single histone mark, however such data need additional confirmation, NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
SIRT7 Polyclonal Antibody |
| Other name: |
Anti-SIRT7 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SIRT7 |
| Short name: |
Anti-SIRT7 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SIRT7 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
14935 |
| Gene: |
SIRT7 |
More about : SIRT7 |
| Long gene name: |
sirtuin 7 |
| Synonyms gene name: |
S, cerevisiae) , homolog) 7 sirtuin (silent mating type information regulation 2 homolog) 7 (S, sirtuin (silent mating type information regulation 2, cerevisiae |
| Locus: |
17q25, 3 |
| Discovery year: |
2001-03-20 |
| GenBank acession: |
AF233395 |
| Entrez gene record: |
51547 |
| Pubmed identfication: |
10873683 16618798 |
| RefSeq identity: |
NM_016538 |
| Classification: |
Sirtuins |
| Havana BLAST/BLAT: |
OTTHUMG00000177957 |