| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TUSC2 |
| Specificity: |
This antibody reacts specifically with TUSC2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TUSC2 |
| Gene ID: |
11334 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
AKT, Expression of TUSC2 protein is absent or reduced in the majority of lung cancers and premalignant lung lesions, PDGFR, Restoration of TUSC2 function in 3p21, TUSC2 may induce apoptosis through the activation of the intrinsic mitochondrial-dependent and Apaf-1-associated pathways and inhibit the function of protein tyrosine kinases including EGFR, and c-Kit, c-Abl, 3 region where allele losses and genetic alterations occur early and frequently for many human cancers, 3-deficient non-small cell lung carcinoma cells significantly inhibits tumor cell growth by induction of apoptosis and alteration of cell cycle kinetics, TUSC2/FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FUS1 PAP C3orf11 |
| Also known as: |
TUSC2 Polyclonal Antibody |
| Other name: |
Anti-TUSC2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TUSC2 |
| Short name: |
Anti-TUSC2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TUSC2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17034 |
| Gene: |
TUSC2 |
More about : TUSC2 |
| Long gene name: |
tumor suppressor candidate 2 |
| Synonyms gene: |
PDAP2 |
| Synonyms gene name: |
PDGFA associated protein 2 |
| Locus: |
3p21, 31 |
| Discovery year: |
2003-09-25 |
| GenBank acession: |
AF055479 |
| Entrez gene record: |
11334 |
| Pubmed identfication: |
8780057 11593436 |
| RefSeq identity: |
NM_007275 |
| Havana BLAST/BLAT: |
OTTHUMG00000156877 |