| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DAXX Ser495 |
| Specificity: |
DAXX (Ser495), This phosphorylation site is homologous to that of Ser505 in Bovine |
| Modification: |
Phosphorylation |
| Modification site: |
Ser495 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human DAXX around the phosphorylation site of Ser495 |
| Gene ID: |
1616 |
| Swiss Prot: |
Q9UER7 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alternative splicing results in multiple transcript variants, In the cytoplasm, In the nucleus, It interacts with a wide variety of proteins, Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli, Nov 2008], The subcellular localization and function of this protein are modulated by post-translational modifications, This protein also associates with centromeres in G2 phase, [provided by RefSeq, and transcription factor erythroblastosis virus E26 oncogene homolog 1, centromere protein C, including sumoylation, phosphorylation and polyubiquitination, such as apoptosis antigen Fas, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors, the encoded protein may function to regulate apoptosis, This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DAP6 |
| Also known as: |
DAXX (Ser495) Polyclonal Antibody |
| Other name: |
Anti-DAXX (Ser495) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DAXX (Ser495) |
| Short name: |
Anti-DAXX (Ser495) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-death-domain associated protein (Ser495) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BING2 and DAP6 and EAP1, DAXX and IDBG-629026 and ENSBTAG00000016830 and 504336, DAXX and IDBG-82726 and ENSG00000204209 and 102723452, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006915 and apoptotic process and biological process this GO :0007257 and activation of JUN kinase activity and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0016605 and PML body and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030295 and protein kinase activator activity and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0031072 and heat shock protein binding and molecular function this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0042393 and histone binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0050681 and androgen receptor binding and molecular function this GO :0070603 and SWI/SNF superfamily-type complex and cellular component this GO :0097190 and apoptotic signaling pathway and biological process this GO :1901216 and positive regulation of neuron death and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, Daxx and IDBG-168138 and ENSMUSG00000002307 and 13163, androgen receptor binding, centromeric region and cellular component this GO :0000792 and heterochromatin and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002039 and p53 binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0005057 and receptor signaling protein activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006334 and nucleosome assembly and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, nuclei, this GO :0000281 and mitotic cytokinesis and biological process this GO :0000775 and chromosome, this GO :0002039 : p53 binding, this GO :0002039 : p53 binding and also this GO :0003714 : transcription corepressor activity and also this GO :0005057 : receptor signaling protein activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0030295 : protein kinase activator activity and also this GO :0031072 : heat shock protein binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0042393 : histone binding and also this GO :0042803 : protein homodimerization activity and also this GO :0047485 : protein N-terminus binding and also this GO :0050681 : androgen receptor binding, this GO :0003714 : transcription corepressor activity, this GO :0005057 : receptor signaling protein activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0030295 : protein kinase activator activity, this GO :0031072 : heat shock protein binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0042393 : histone binding, this GO :0042803 : protein homodimerization activity, this GO :0047485 : protein N-terminus binding, this GO :0050681 : androgen receptor binding, 1616, death-domain associated protein |
| Identity: |
2681 |
| Gene: |
DAXX |
More about : DAXX |
| Long gene name: |
death domain associated protein |
| Synonyms gene name: |
death-associated protein 6 |
| Locus: |
6p21, 32 |
| Discovery year: |
1998-03-25 |
| GenBank acession: |
AF006041 |
| Entrez gene record: |
1616 |
| Pubmed identfication: |
9407001 9215629 |
| Havana BLAST/BLAT: |
OTTHUMG00000031203 |