| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
APBB1 Ser175 |
| Specificity: |
This antibody reacts specifically with APBB1 (Ser175) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser175 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human APBB1 around the phosphorylation site of Ser175 [LS(p-S)PP] |
| Gene ID: |
322 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation, Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression, It interacts with the Alzheimer's disease amyloid precursor protein (APP), It is an adaptor protein localized in the nucleus, It is thought to regulate transcription, Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, This encoded protein could play an important role in the pathogenesis of Alzheimer's disease, transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein, The protein encoded by this gene is a member of the Fe65 protein family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Fe65 |
| Also known as: |
APBB1 (Ser175) Polyclonal Antibody |
| Other name: |
Anti-APBB1 (Ser175) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
APBB1 (Ser175) |
| Short name: |
Anti-APBB1 (Ser175) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, family B, member 1 (Fe65) (Ser175) (polyclonal), antibody to-amyloid b (A4) precursor protein-binding |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
APBB1 and IDBG-28785 and ENSG00000166313 and 322, APBB1 and IDBG-634164 and ENSBTAG00000015655 and 505096, Apbb1 and IDBG-204734 and ENSMUSG00000037032 and 11785, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007165 and signal transduction and biological process this GO :0007409 and axonogenesis and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0016607 and nuclear speck and cellular component this GO :0030027 and lamellipodium and cellular component this GO :0030308 and negative regulation of cell growth and biological process this GO :0030426 and growth cone and cellular component this GO :0042393 and histone binding and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043967 and histone H4 acetylation and biological process this GO :0045202 and synapse and cellular component this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0050760 and negative regulation of thymidylate synthase biosynthetic process and biological process this GO :0070064 and proline-rich region binding and molecular function, FE65 and MGC:9072 and RIR, family B, member 1 (Fe65), nuclei, proline-rich region binding, this GO :0001540 and beta-amyloid binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0001540 : beta-amyloid binding, this GO :0001540 : beta-amyloid binding and also this GO :0003682 : chromatin binding and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0042393 : histone binding and also this GO :0070064 : proline-rich region binding, this GO :0003682 : chromatin binding, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0042393 : histone binding, this GO :0070064 : proline-rich region binding, amyloid beta (A4) precursor protein-binding |
| Identity: |
581 |
| Gene: |
APBB1 |
More about : APBB1 |
| Long gene name: |
amyloid beta precursor protein binding family B member 1 |
| Synonyms gene: |
RIR |
| Synonyms gene name: |
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) |
| Locus: |
11p15, 4 |
| Discovery year: |
1997-03-27 |
| GenBank acession: |
L77864 |
| Entrez gene record: |
322 |
| Pubmed identfication: |
8955346 8894693 |
| RefSeq identity: |
NM_001164 |
| Havana BLAST/BLAT: |
OTTHUMG00000165454 |