| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CD44 |
| Specificity: |
This antibody reacts specifically with CD44 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CD44/HPGP1 |
| Gene ID: |
960 |
| Swiss Prot: |
P16070 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Adhesion with HA plays an important role in cell migration, Also involved in lymphocyte activation, Altered expression or dysfunction causes numerous pathogenic phenotypes, Great protein heterogeneity due to numerous alternative splicing and post-translational modification events, In cancer cells, Mediates cell-cell and cell-matrix interactions through its affinity for HA, and in hematopoiesis, and matrix metalloproteinases (MMPs), and possibly also through its affinity for other ligands such as osteopontin, collagens, may play an important role in invadopodia formation, recirculation and homing, tumor growth and progression, Receptor for hyaluronic acid (HA) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IN MC56 Pgp1 CD44R HCELL CSPG8 |
| Also known as: |
CD44 Polyclonal Antibody |
| Other name: |
Anti-CD44 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CD44 |
| Short name: |
Anti-CD44 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CD44 molecule (Indian blood group) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CD44 and IDBG-39556 and ENSG00000026508 and 960, CD44 and IDBG-636564 and ENSBTAG00000011578 and 281057, CDW44 and CSPG8 and ECMR-III and HCELL and HUTCH-I and IN and LHR and MC56 and MDU2 and MDU3 and MIC4 and Pgp1, Cd44 and IDBG-193505 and ENSMUSG00000005087 and 12505, Cell surfaces, hyaluronic acid binding, signal transduction by p53 class mediator and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0044344 and cellular response to fibroblast growth factor stimulus and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051216 and cartilage development and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060442 and branching involved in prostate gland morphogenesis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070487 and monocyte aggregation and biological process this GO :1900625 and positive regulation of monocyte aggregation and biological process this GO :1902166 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process, this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0002246 and wound healing involved in inflammatory response and biological process this GO :0004415 and hyalurononglucosaminidase activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005540 and hyaluronic acid binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005975 and carbohydrate metabolic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007596 and blood coagulation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0016020 and membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030203 and glycosaminoglycan metabolic process and biological process this GO :0030212 and hyaluronan metabolic process and biological process this GO :0030214 and hyaluronan catabolic process and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0034116 and positive regulation of heterotypic cell-cell adhesion and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043518 and negative regulation of DNA damage response, this GO :0004415 : hyalurononglucosaminidase activity, this GO :0004415 : hyalurononglucosaminidase activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005515 : protein binding and also this GO :0005518 : collagen binding and also this GO :0005540 : hyaluronic acid binding, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005515 : protein binding, this GO :0005518 : collagen binding, this GO :0005540 : hyaluronic acid binding, CD44 molecule (Indian blood group) |
| Identity: |
1681 |
| Gene: |
CD44 |
More about : CD44 |
| Long gene name: |
CD44 molecule (Indian blood group) |
| Synonyms gene: |
MIC4 MDU2 MDU3 |
| Synonyms gene name: |
CD44 antigen (homing function and Indian blood group system) |
| Synonyms name: |
hematopoietic cell E- and L-selectin ligand chondroitin sulfate proteoglycan 8 |
| Locus: |
11p13 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
M59040 |
| Entrez gene record: |
960 |
| Pubmed identfication: |
2454887 |
| RefSeq identity: |
NM_000610 |
| Classification: |
Proteoglycans CD molecules Blood group antigens |
| Havana BLAST/BLAT: |
OTTHUMG00000044388 |
| Locus Specific Databases: |
LRG_815 |