| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CXCR7/RDC1 |
| Specificity: |
This antibody reacts specifically with CXCR7/RDC1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CXCR7/RDC1 |
| Gene ID: |
57007 |
| Swiss Prot: |
P25106 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1, Acts as coreceptor with CXCR4 for a restricted number of HIV isolates, Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor, Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, In glioma cells, Not involved in cell migration, Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12, Promotes cell growth and survival, Required for heart valve development, Required for regulation of CXCR4 protein levels in migrating interneurons, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, degradation, leading to ligand internalization and activation of MAPK signaling pathway, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration, mediating resistance to apoptosis, or transcytosis, resulting instead in chemokine sequestration, thereby adapting their chemokine responsiveness, transduces signals via MEK/ERK pathway, Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
RDC1 GPR159 |
| Also known as: |
CXCR7/RDC1 Polyclonal Antibody |
| Other name: |
Anti-CXCR7/RDC1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CXCR7/RDC1 |
| Short name: |
Anti-CXCR7/RDC1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-X-C motif) receptor 7/RDC1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C-X-C chemokine binding, CXCR7 and IDBG-642053 and ENSBTAG00000018424 and 509585, CXCR7 and IDBG-84146 and ENSG00000144476 and 57007, Cell surfaces, Cxcr7 and IDBG-179969 and ENSMUSG00000044337 and 12778, this GO :0001525 and angiogenesis and biological process this GO :0001570 and vasculogenesis and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005905 and coated pit and cellular component this GO :0006935 and chemotaxis and biological process this GO :0007155 and cell adhesion and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0019958 and C-X-C chemokine binding and molecular function this GO :0031623 and receptor internalization and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0055037 and recycling endosome and cellular component this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :1902230 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0005044 : scavenger receptor activity and also this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019958 : C-X-C chemokine binding, this GO :0005044 : scavenger receptor activity, this GO :0005515 : protein binding, this GO :0015026 : coreceptor activity, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019958 : C-X-C chemokine binding, chemokine (C-X-C motif) receptor 7 |
| Identity: |
23692 |
| Gene: |
ACKR3 |
More about : ACKR3 |
| Long gene name: |
atypical chemokine receptor 3 |
| Synonyms gene: |
CMKOR1 CXCR7 |
| Synonyms gene name: |
chemokine orphan receptor 1 chemokine (C-X-C motif) receptor 7 |
| Locus: |
2q37, 3 |
| Discovery year: |
2003-12-01 |
| GenBank acession: |
BC008459 |
| Entrez gene record: |
57007 |
| Pubmed identfication: |
16107333 16148 |
| RefSeq identity: |
NM_020311 |
| Classification: |
Atypical chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133295 |