| Long name: |
ALEXA FLUOR 488 Conjugated, CXCR7 Polyclonal Antibody |
| Also known as: |
Anti-CXCR7 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CXCR7 |
| Specificity: |
This is a highly specific antibody against CXCR7 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
312-362/362 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CXCR7 |
| Gene ID Number: |
57007 |
| Swiss Prot: |
P25106 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1, Acts as coreceptor with CXCR4 for a restricted number of HIV isolates, Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor, Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, In glioma cells, Not involved in cell migration, Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12, Promotes cell growth and survival, Required for heart valve development, Required for regulation of CXCR4 protein levels in migrating interneurons, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, degradation, leading to ligand internalization and activation of MAPK signaling pathway, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration, mediating resistance to apoptosis, or transcytosis, resulting instead in chemokine sequestration, thereby adapting their chemokine responsiveness, transduces signals via MEK/ERK pathway, Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
RDC1 GPR159 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the CXCR7 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
CXCR7 |
| Short name: |
CXCR7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, chemokine (C-X-C motif) receptor 7 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C-X-C chemokine binding, CXCR7 and IDBG-642053 and ENSBTAG00000018424 and 509585, CXCR7 and IDBG-84146 and ENSG00000144476 and 57007, Cell surfaces, Cxcr7 and IDBG-179969 and ENSMUSG00000044337 and 12778, this GO :0001525 and angiogenesis and biological process this GO :0001570 and vasculogenesis and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005905 and coated pit and cellular component this GO :0006935 and chemotaxis and biological process this GO :0007155 and cell adhesion and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0019958 and C-X-C chemokine binding and molecular function this GO :0031623 and receptor internalization and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0055037 and recycling endosome and cellular component this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :1902230 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0005044 : scavenger receptor activity and also this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019958 : C-X-C chemokine binding, this GO :0005044 : scavenger receptor activity, this GO :0005515 : protein binding, this GO :0015026 : coreceptor activity, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019958 : C-X-C chemokine binding, chemokine (C-X-C motif) receptor 7 |
| Identity: |
23692 |
| Gene: |
ACKR3 |
More about : ACKR3 |
| Long gene name: |
atypical chemokine receptor 3 |
| Synonyms gene: |
CMKOR1 CXCR7 |
| Synonyms gene name: |
chemokine orphan receptor 1 chemokine (C-X-C motif) receptor 7 |
| Locus: |
2q37, 3 |
| Discovery year: |
2003-12-01 |
| GenBank acession: |
BC008459 |
| Entrez gene record: |
57007 |
| Pubmed identfication: |
16107333 16148 |
| RefSeq identity: |
NM_020311 |
| Classification: |
Atypical chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133295 |