| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TGF Beta 1+2+3 |
| Specificity: |
TGF Beta 1+2+3, but will also detect TGFB2 (93%) and TGFB3 (86%) based upon sequence similarity, This antibody will preferentially react with TGFB1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted, Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TGF Beta 1 |
| Gene ID: |
7040 |
| Swiss Prot: |
P01137 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
At high concentrations, At low concentrations in concert with IL-6 and IL-21, Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner, It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, It positively and negatively regulates many other growth factors, Many cells synthesize TGFB1 and have specific receptors for it, causing chemotaxis, differentiation and other functions in many cell types, favoring Treg cell development, favoring differentiation to Th17 cells, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, leads to expression of the IL-17 and IL-23 receptors, proliferation and differentiation in committed osteoblasts, Multifunctional protein that controls proliferation |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DPD1, LAP, TGF-beta-1, TGFB, TGFB1, TGFbeta, Transforming growth factor beta-1, CED |
| Also known as: |
TGF Beta 1+2+3 Polyclonal Antibody |
| Other name: |
Anti-TGF Beta 1+2+3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TGF Beta 1+2+3 |
| Short name: |
Anti-TGF Beta 1+2+3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TGF b 1+2+3 (polyclonal) |
| Alternative technique: |
polyclonals |