| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BPI |
| Specificity: |
This antibody reacts specifically with BPI |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BPI |
| Gene ID: |
671 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils, Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS, The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BPIFD1 |
| Also known as: |
BPI Polyclonal Antibody |
| Other name: |
Anti-BPI Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BPI |
| Short name: |
Anti-BPI (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-bactericidal/permeability-increasing protein (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BPI and IDBG-642592 and ENSBTAG00000014046 and 280734, BPI and IDBG-74654 and ENSG00000101425 and 149684, BPIFD1 and rBPI, Bpi and IDBG-211473 and ENSMUSG00000052922 and 329547, Plasma membranes, lipid binding, this GO :0001530 and lipopolysaccharide binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0008289 and lipid binding and molecular function this GO :0032715 and negative regulation of interleukin-6 production and biological process this GO :0032717 and negative regulation of interleukin-8 production and biological process this GO :0032720 and negative regulation of tumor necrosis factor production and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0043031 and negative regulation of macrophage activation and biological process this GO :0045087 and innate immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001530 : lipopolysaccharide binding, this GO :0001530 : lipopolysaccharide binding and also this GO :0008289 : lipid binding, this GO :0008289 : lipid binding, 671, bactericidal/permeability-increasing protein |
| Identity: |
1095 |
| Gene: |
BPI |
More about : BPI |
| Long gene name: |
bactericidal/permeability-increasing protein |
| Synonyms name: |
BPI fold containing family D, member 1 |
| Locus: |
20q11, 23 |
| Discovery year: |
1992-03-13 |
| GenBank acession: |
J04739 |
| Entrez gene record: |
671 |
| Pubmed identfication: |
8432532 |
| RefSeq identity: |
NM_001725 |
| Classification: |
BPI fold containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032441 |