| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
VAPB |
| Specificity: |
This antibody reacts specifically with VAPB |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human VAPB |
| Gene ID: |
9217 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980], Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, The patients show a benign course, This form is a late adult onset form of the disease (after age 20 years), also called late onset spinal muscular atrophy Finkel type, leading to progressive paralysis muscular atrophy, most of them remaining ambulatory 10 to 40 years after clinical onset, VAPB contains 1 MSP domain and it may play a role in vesicle trafficking |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
VAP-B VAP-C ALS8 |
| Also known as: |
VAPB Polyclonal Antibody |
| Other name: |
Anti-VAPB Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
VAPB |
| Short name: |
Anti-VAPB (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-VAPB (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
12649 |
| Gene: |
VAPB |
More about : VAPB |
| Long gene name: |
VAMP associated protein B and C |
| Synonyms gene name: |
VAMP (vesicle-associated membrane protein)-associated protein B and C |
| Locus: |
20q13, 32 |
| Discovery year: |
1999-03-19 |
| GenBank acession: |
AF086628 |
| Entrez gene record: |
9217 |
| Pubmed identfication: |
9920726 |
| Havana BLAST/BLAT: |
OTTHUMG00000032840 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_656 |