| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TAB1 |
| Specificity: |
This antibody reacts specifically with TAB1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MAP3K7IP1/TAB1 |
| Gene ID: |
10454 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, This protein, activates TAK1 kinase in response to upstream signals, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses, together with either TAB2 or TAB3, which is known to mediate various intracellular signaling pathways, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
TAB1 Polyclonal Antibody |
| Other name: |
Anti-TAB1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TAB1 |
| Short name: |
Anti-TAB1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TGF-beta activated kinase 1/MAP3K7 binding protein 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
3\'-Tab1 and MAP3K7IP1, MAP3K7IP1 and IDBG-641725 and ENSBTAG00000019828 and 519958, TAB1 and IDBG-8281 and ENSG00000100324 and 10454, Tab1 and IDBG-163423 and ENSMUSG00000022414 and 66513, leucine rich repeat containing receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043234 and protein complex and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0048273 and mitogen-activated protein kinase p38 binding and molecular function this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process, mitogen-activated protein kinase p38 binding, nuclei, this GO :0000185 and activation of MAPKKK activity and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003824 and catalytic activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0007254 and JNK cascade and biological process this GO :0008047 and enzyme activator activity and molecular function this GO :0010008 and endosome membrane and cellular component this GO :0019209 and kinase activator activity and molecular function this GO :0030324 and lung development and biological process this GO :0032403 and protein complex binding and molecular function this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0005515 : protein binding and also this GO :0008047 : enzyme activator activity and also this GO :0019209 : kinase activator activity and also this GO :0032403 : protein complex binding and also this GO :0048273 : mitogen-activated protein kinase p38 binding, this GO :0005515 : protein binding, this GO :0008047 : enzyme activator activity, this GO :0019209 : kinase activator activity, this GO :0032403 : protein complex binding, this GO :0048273 : mitogen-activated protein kinase p38 binding, TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Identity: |
18157 |
| Gene: |
TAB1 |
More about : TAB1 |
| Long gene name: |
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 |
| Synonyms gene: |
MAP3K7IP1 |
| Synonyms gene name: |
mitogen-activated protein kinase kinase kinase 7 interacting protein 1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Synonyms name: |
TAK1-binding protein 1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 |
| Locus: |
22q13, 1 |
| Discovery year: |
2002-02-22 |
| GenBank acession: |
U49928 |
| Entrez gene record: |
10454 |
| Pubmed identfication: |
8638164 10187861 |
| RefSeq identity: |
NM_153497 |
| Havana BLAST/BLAT: |
OTTHUMG00000151102 |