| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CASC3 |
| Specificity: |
This antibody reacts specifically with CASC3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CASC3/MLN51 |
| Gene ID: |
22794 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes, In mammalian cells, Its fly homolog, MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer, Magoh and Y14, The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, The function of MLN51 in mammals remains elusive, and translation, are core components of the exon junction complex (EJC), as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte, named barentsz, nonsense-mediated mRNA decay, the human homologs of mago nashi and tsunagi, this complex serves as a key modulator of spliced mRNA metabolism, &euro, &ldquo, The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonâ, exon junctions as a consequence of pre-mRNA splicing |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MLN51 BTZ |
| Also known as: |
CASC3 Polyclonal Antibody |
| Other name: |
Anti-CASC3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CASC3 |
| Short name: |
Anti-CASC3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CASC3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17040 |
| Gene: |
CASC3 |
More about : CASC3 |
| Long gene name: |
cancer susceptibility 3 |
| Synonyms gene name: |
cancer susceptibility candidate 3 |
| Locus: |
17q21, 1 |
| Discovery year: |
2004-02-11 |
| GenBank acession: |
X80199 |
| Entrez gene record: |
22794 |
| Pubmed identfication: |
7490069 18332872 |
| RefSeq identity: |
NM_007359 |
| Classification: |
Exon junction complex |
| Havana BLAST/BLAT: |
OTTHUMG00000133323 |