| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CYP8A1/PTGIS |
| Specificity: |
This antibody reacts specifically with CYP8A1/PTGIS |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CYP8A1/PTGIS |
| Gene ID: |
5740 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, However, The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation, and atherosclerosis, steroids and other lipids, stroke, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity, This gene encodes a member of the cytochrome P450 superfamily of enzymes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PGIS CYP8A1 |
| Also known as: |
CYP8A1/PTGIS Polyclonal Antibody |
| Other name: |
Anti-CYP8A1/PTGIS Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CYP8A1/PTGIS |
| Short name: |
Anti-CYP8A1/PTGIS (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CYP8A1/prostaglandin I2 (prostacyclin) synthase (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CYP8 and CYP8A1 and PGIS and PTGI, PTGIS and IDBG-643178 and ENSBTAG00000017537 and 101910090, PTGIS and IDBG-80513 and ENSG00000124212 and 5740, Ptgis and IDBG-213024 and ENSMUSG00000017969 and 19223, acting on paired donors, acting on paired donors, acting on paired donors, nuclei, oxidoreductase activity, this GO :0001516 and prostaglandin biosynthetic process and biological process this GO :0004497 and monooxygenase activity and molecular function this GO :0005506 and iron ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006690 and icosanoid metabolic process and biological process this GO :0006805 and xenobiotic metabolic process and biological process this GO :0008116 and prostaglandin-I synthase activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016705 and oxidoreductase activity, this GO :0004497 : monooxygenase activity, this GO :0004497 : monooxygenase activity and also this GO :0005506 : iron ion binding and also this GO :0005515 : protein binding and also this GO :0008116 : prostaglandin-I synthase activity and also this GO :0016705 : oxidoreductase activity, this GO :0005506 : iron ion binding, this GO :0005515 : protein binding, this GO :0008116 : prostaglandin-I synthase activity, this GO :0016705 : oxidoreductase activity, this GO :0020037 : heme binding, with incorporation or reduction of molecular oxygen, with incorporation or reduction of molecular oxygen and also this GO :0020037 : heme binding, with incorporation or reduction of molecular oxygen and molecular function this GO :0019369 and arachidonic acid metabolic process and biological process this GO :0019371 and cyclooxygenase pathway and biological process this GO :0020037 and heme binding and molecular function this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0035360 and positive regulation of peroxisome proliferator activated receptor signaling pathway and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045019 and negative regulation of nitric oxide biosynthetic process and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0071347 and cellular response to interleukin-1 and biological process this GO :0071354 and cellular response to interleukin-6 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :1900119 and positive regulation of execution phase of apoptosis and biological process, 282021, prostaglandin I2 (prostacyclin) synthase |
| Identity: |
9603 |
| Gene: |
PTGIS |
More about : PTGIS |
| Long gene name: |
prostaglandin I2 synthase |
| Synonyms gene name: |
prostaglandin I2 (prostacyclin) synthase |
| Synonyms name: |
cytochrome P450, family 8, polypeptide 1 prostacyclin synthase , subfamily A |
| Locus: |
20q13, 13 |
| Discovery year: |
1994-07-28 |
| Entrez gene record: |
5740 |
| Pubmed identfication: |
8812456 |
| Classification: |
Cytochrome P450 family 8 |
| Havana BLAST/BLAT: |
OTTHUMG00000033077 |
| Locus Specific Databases: |
Human Cytochrome P450 (CYP) Allele Nomenclature Committee |