| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PBR |
| Specificity: |
This antibody reacts specifically with PBR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Peripheral type Benzodiazepine Receptor |
| Gene ID: |
1622 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A short form, It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC), It is speculated that patients with congenital lipoid adrenal hyperplasia, It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis, PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis, PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR, might have a genetic lesion in BZRP, who cannot make any steroids, PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PBR MBR PKBS mDRC DBI IBP pk18 |
| Also known as: |
PBR Polyclonal Antibody |
| Other name: |
Anti-PBR Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PBR |
| Short name: |
Anti-PBR (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PBR (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
1158 |
| Gene: |
TSPO |
More about : TSPO |
| Long gene name: |
translocator protein |
| Synonyms gene: |
BZRP |
| Synonyms gene name: |
benzodiazapine receptor (peripheral) translocator protein (18kDa) |
| Synonyms name: |
peripheral-type benzodiazepine receptor/recognition site |
| Locus: |
22q13, 2 |
| Discovery year: |
1991-05-25 |
| GenBank acession: |
AF075589 |
| Entrez gene record: |
706 |
| Pubmed identfication: |
1326278 1847678 16822554 |
| RefSeq identity: |
NM_007311 |
| Havana BLAST/BLAT: |
OTTHUMG00000150573 |