| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MST1 |
| Specificity: |
This antibody reacts specifically with MST1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MST1 |
| Gene ID: |
6789 |
| Swiss Prot: |
Q13043 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as an inhibitor of PKB/AKT1, Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, MOBKL1B and RASSF2, Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis, Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes, Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner, Phosphorylates FOXO3 upon oxidative stress, Phosphorylates MOBKL1A, Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T), Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, and to inhibit tumor formation (By similarity), cell death, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation, following caspase-cleavage, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, pro-apoptotic kinase which, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage, to prevent activation of facultative adult liver stem cells (oval cells), which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, which results in its nuclear translocation and cell death initiation, Stress-activated |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MST1 KRS2 YSK3 |
| Also known as: |
MST1 Polyclonal Antibody |
| Other name: |
Anti-MST1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MST1 |
| Short name: |
Anti-MST1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-macrophage stimulating 1 (hepatocyte growth factor-like) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, D3F15S2 and DNF15S2 and HGFL and MSP and NF15S2, MST1 and IDBG-35033 and ENSG00000173531 and 4485, Mst1 and IDBG-199175 and ENSMUSG00000032591 and 15235, multiple, serine-type endopeptidase activity, this GO :0003674 and molecular function and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0006508 and proteolysis and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007566 and embryo implantation and biological process this GO :0008150 and biological process and biological process this GO :0030317 and sperm motility and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0003674 : molecular_function, this GO :0003674 : molecular_function and also this GO :0003824 : catalytic activity and also this GO :0004252 : serine-type endopeptidase activity, this GO :0003824 : catalytic activity, this GO :0004252 : serine-type endopeptidase activity, 60953 and IDBG-645967 and ENSBTAG00000011585 and 514667, macrophage stimulating 1 (hepatocyte growth factor-like) |
| Identity: |
11408 |
| Gene: |
STK4 |
More about : STK4 |
| Long gene name: |
serine/threonine kinase 4 |
| Synonyms name: |
mammalian sterile 20-like 1 yeast Ste20-like kinase responsive to stress 2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1997-10-09 |
| Entrez gene record: |
6789 |
| Pubmed identfication: |
8816758 9545236 11517310 |
| RefSeq identity: |
NM_006282 |
| Havana BLAST/BLAT: |
OTTHUMG00000033059 |
| Locus Specific Databases: |
LRG_535 |