| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SATB1 Ser47 |
| Specificity: |
This antibody reacts specifically with SATB1 (Ser47) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser47 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human SATB1 around the phosphorylation site of Ser47 |
| Gene ID: |
6304 |
| Swiss Prot: |
Q01826 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a docking site for several chromatin remodeling enzymes (e, Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery, Binds to DNA at special AT-rich sequences, Delineates specific epigenetic modifications at target gene loci, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1, Interacts with the unique region (UR) of cytomegalovirus (CMV), Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes, Moreover, PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers, Plays a role in chromatin organization and nuclear architecture during apoptosis, Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis, Required for the switching of fetal globin species, Thought to recognize the sugar-phosphate structure of double-stranded DNA, Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, and beta- and gamma-globin genes regulation during erythroid differentiation, at nuclear matrix- or scaffold-associated regions, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes, the consensus SATB1-binding sequence (CSBS), Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity), g |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
SATB1 (Ser47) Polyclonal Antibody |
| Other name: |
Anti-SATB1 (Ser47) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SATB1 (Ser47) |
| Short name: |
Anti-SATB1 (Ser47) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SATB homeobox 1 (Ser47) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006915 and apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0008544 and epidermis development and biological process this GO :0016032 and viral process and biological process this GO :0016363 and nuclear matrix and cellular component this GO :0016571 and histone methylation and biological process this GO :0016605 and PML body and cellular component this GO :0042110 and T cell activation and biological process this GO :0043367 and CD4-positive, SATB1 and IDBG-21555 and ENSG00000182568 and 6304, SATB1 and IDBG-640809 and ENSBTAG00000021158 and 516952, Satb1 and IDBG-190608 and ENSMUSG00000023927 and 20230, alpha-beta T cell differentiation and biological process this GO :0043374 and CD8-positive, alpha-beta T cell differentiation and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0050798 and activated T cell proliferation and biological process this GO :0060004 and reflex and biological process, nuclei, sequence-specific DNA binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000785 and chromatin and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005720 and nuclear heterochromatin and cellular component this GO :0006325 and chromatin organization and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0043565 : sequence-specific DNA binding, this GO :0003682 : chromatin binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0043565 : sequence-specific DNA binding, SATB homeobox 1 |
| Identity: |
10541 |
| Gene: |
SATB1 |
More about : SATB1 |
| Long gene name: |
SATB homeobox 1 |
| Synonyms gene name: |
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA) |
| Locus: |
3p24, 3 |
| Discovery year: |
1994-05-03 |
| Entrez gene record: |
6304 |
| Pubmed identfication: |
1505028 |
| RefSeq identity: |
NM_001131010 |
| Classification: |
CUT class homeoboxes and pseudogenes |
| Havana BLAST/BLAT: |
OTTHUMG00000129890 |