| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ADRB2 Ser346 |
| Specificity: |
This antibody reacts specifically with ADRB2 (Ser346) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser346 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human ADRB2 around the phosphorylation site of Ser346 |
| Gene ID: |
154 |
| Swiss Prot: |
P07550 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine, Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ADRBR BAR B2AR |
| Also known as: |
ADRB2 (Ser346) Polyclonal Antibody |
| Other name: |
Anti-ADRB2 (Ser346) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ADRB2 (Ser346) |
| Short name: |
Anti-ADRB2 (Ser346) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, surface (Ser346) (polyclonal), antibody to-adrenoceptor b 2 |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ADRB2 and IDBG-52685 and ENSG00000169252 and 154, ADRB2 and IDBG-648668 and ENSBTAG00000002144 and 281605, ADRB2R and ADRBR and B2AR and BAR and BETA2AR, Adrb2 and IDBG-152615 and ENSMUSG00000045730 and 11555, norepinephrine binding, nuclei, surface, this GO :0001993 and regulation of systemic arterial blood pressure by norepinephrine-epinephrine and biological process this GO :0002024 and diet induced thermogenesis and biological process this GO :0002025 and vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure and biological process this GO :0002028 and regulation of sodium ion transport and biological process this GO :0002032 and desensitization of G-protein coupled receptor protein signaling pathway by arrestin and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004941 and beta2-adrenergic receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005764 and lysosome and cellular component this GO :0005768 and endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007171 and activation of transmembrane receptor protein tyrosine kinase activity and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007188 and adenylate cyclase-modulating G-protein coupled receptor signaling pathway and biological process this GO :0007189 and adenylate cyclase-activating G-protein coupled receptor signaling pathway and biological process this GO :0007190 and activation of adenylate cyclase activity and biological process this GO :0008179 and adenylate cyclase binding and molecular function this GO :0008333 and endosome to lysosome transport and biological process this GO :0009409 and response to cold and biological process this GO :0015459 and potassium channel regulator activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0030501 and positive regulation of bone mineralization and biological process this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031649 and heat generation and biological process this GO :0040015 and negative regulation of multicellular organism growth and biological process this GO :0042312 and regulation of vasodilation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043235 and receptor complex and cellular component this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045453 and bone resorption and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0045986 and negative regulation of smooth muscle contraction and biological process this GO :0050873 and brown fat cell differentiation and biological process this GO :0051380 and norepinephrine binding and molecular function this GO :0071875 and adrenergic receptor signaling pathway and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004941 : beta2-adrenergic receptor activity and also this GO :0005515 : protein binding and also this GO :0008179 : adenylate cyclase binding and also this GO :0015459 : potassium channel regulator activity and also this GO :0019899 : enzyme binding and also this GO :0042803 : protein homodimerization activity and also this GO :0051380 : norepinephrine binding, this GO :0004941 : beta2-adrenergic receptor activity, this GO :0005515 : protein binding, this GO :0008179 : adenylate cyclase binding, this GO :0015459 : potassium channel regulator activity, this GO :0019899 : enzyme binding, this GO :0042803 : protein homodimerization activity, this GO :0051380 : norepinephrine binding, adrenoceptor beta 2 |
| Identity: |
286 |
| Gene: |
ADRB2 |
More about : ADRB2 |
| Long gene name: |
adrenoceptor beta 2 |
| Synonyms gene: |
ADRB2R |
| Synonyms gene name: |
adrenergic, beta-2-, receptor, surface , surface adrenoceptor beta 2 |
| Locus: |
5q32 |
| Discovery year: |
1990-09-10 |
| GenBank acession: |
AF022953 |
| Entrez gene record: |
154 |
| RefSeq identity: |
NM_000024 |
| Classification: |
Adrenoceptors |
| Havana BLAST/BLAT: |
OTTHUMG00000129933 |