| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CITED1 |
| Specificity: |
This antibody reacts specifically with CITED1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CITED1 |
| Gene ID: |
4435 |
| Swiss Prot: |
Q99966 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling, Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner, Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex, Induces transcription from estrogen-responsive promoters and protection against cell death, May play a role in pigmentation of melanocytes, Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex, Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter, Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling, stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300, Transcriptional coactivator of the p300/CBP-mediated trancription complex |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
CITED1 Polyclonal Antibody |
| Other name: |
Anti-CITED1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CITED1 |
| Short name: |
Anti-CITED1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
1 (polyclonal), ALEXA Fluor 594, including L-gutamic acid/L-aspartic acid-rich carboxy-terminal domain, antibody to-Cbp/p300-interacting transactivator |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
1, CITED1 and IDBG-635694 and ENSBTAG00000045925 and 282182, CITED1 and IDBG-76674 and ENSG00000125931 and 4435, Cited1 and IDBG-164976 and ENSMUSG00000051159 and 12705, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006913 and nucleocytoplasmic transport and biological process this GO :0006915 and apoptotic process and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007420 and brain development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030318 and melanocyte differentiation and biological process this GO :0030511 and positive regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032868 and response to insulin and biological process this GO :0034097 and response to cytokine and biological process this GO :0034341 and response to interferon-gamma and biological process this GO :0042438 and melanin biosynthetic process and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043473 and pigmentation and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043627 and response to estrogen and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0050693 and LBD domain binding and molecular function this GO :0051591 and response to cAMP and biological process this GO :0060231 and mesenchymal to epithelial transition and biological process this GO :0060395 and SMAD protein signal transduction and biological process this GO :0060711 and labyrinthine layer development and biological process this GO :0060712 and spongiotrophoblast layer development and biological process this GO :0070410 and co-SMAD binding and molecular function this GO :0070555 and response to interleukin-1 and biological process this GO :0070669 and response to interleukin-2 and biological process this GO :0070670 and response to interleukin-4 and biological process this GO :0070741 and response to interleukin-6 and biological process this GO :0071104 and response to interleukin-9 and biological process this GO :0071105 and response to interleukin-11 and biological process this GO :0071107 and response to parathyroid hormone and biological process this GO :0071559 and response to transforming growth factor beta and biological process, MSG1, co-SMAD binding, nuclei, this GO :0000578 and embryonic axis specification and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001656 and metanephros development and biological process this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0001890 and placenta development and biological process this GO :0003340 and negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003682 : chromatin binding, this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003713 : transcription coactivator activity and also this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0042803 : protein homodimerization activity and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0050693 : LBD domain binding and also this GO :0070410 : co-SMAD binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003713 : transcription coactivator activity, this GO :0005515 : protein binding, this GO :0008022 : protein C-terminus binding, this GO :0042803 : protein homodimerization activity, this GO :0044212 : transcription regulatory region DNA binding, this GO :0050693 : LBD domain binding, this GO :0070410 : co-SMAD binding, with Glu/Asp-rich carboxy-terminal domain, Cbp/p300-interacting transactivator |
| Identity: |
1986 |
| Gene: |
CITED1 |
More about : CITED1 |
| Long gene name: |
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 |
| Synonyms gene: |
MSG1 |
| Synonyms gene name: |
1 , Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain |
| Locus: |
Xq13, 1 |
| Discovery year: |
1998-03-27 |
| GenBank acession: |
U65092 |
| Entrez gene record: |
4435 |
| Pubmed identfication: |
8901575 9721210 |
| RefSeq identity: |
NM_004143 |
| Havana BLAST/BLAT: |
OTTHUMG00000021812 |
| Locus Specific Databases: |
Mental Retardation database |