| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
OXSR1 |
| Specificity: |
This antibody reacts specifically with OXSR1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human OXSR1 |
| Gene ID: |
9943 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binds to and phosphorylates RELL1, NaCl, OXSR1 interacts with chloride channel proteins SLC12A6 isoform 2, OXSR1 may have a role in regulating the actin cytoskeleton, OXSR1 phosphorylated thr84 within the N-terminal regulatory domain of PAK1, RELL2 AND RELT, Replacement of thr84 with gln reduced activation of PAK1 by an active form of the small G protein CDC42, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, notably sorbitol and, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress, suggesting that phosphorylation by OXSR1 modulates the G protein sensitivity of PAK, to a lesser extent, OXSR1 is a serine/threonine kinase which regulates downstream kinases in response to environmental stress such as osmotic stresses |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1101 |
| Also known as: |
OXSR1 Polyclonal Antibody |
| Other name: |
Anti-OXSR1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
OXSR1 |
| Short name: |
Anti-OXSR1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-oxidative-stress responsive 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cytoplasm, OSR1, OXSR1 and IDBG-25753 and ENSG00000172939 and 9943, OXSR1 and IDBG-644304 and ENSBTAG00000014927 and 526949, Oxsr1 and IDBG-204530 and ENSMUSG00000036737 and 108737, this GO :0000287 and magnesium ion binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071476 and cellular hypotonic response and biological process this GO :1901017 and negative regulation of potassium ion transmembrane transporter activity and biological process this GO :1901380 and negative regulation of potassium ion transmembrane transport and biological process this GO :2000681 and negative regulation of rubidium ion transport and biological process this GO :2000687 and negative regulation of rubidium ion transmembrane transporter activity and biological process, oxidative-stress responsive 1 |
| Identity: |
8508 |
| Gene: |
OXSR1 |
More about : OXSR1 |
| Long gene name: |
oxidative stress responsive 1 |
| Synonyms gene: |
OSR1 |
| Synonyms gene name: |
oxidative-stress responsive 1 |
| Locus: |
3p22, 2 |
| Discovery year: |
1999-05-06 |
| GenBank acession: |
AB017642 |
| Entrez gene record: |
9943 |
| Pubmed identfication: |
10083736 |
| RefSeq identity: |
NM_005109 |
| Havana BLAST/BLAT: |
OTTHUMG00000131084 |