| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HDAC6 |
| Specificity: |
This antibody reacts specifically with HDAC6 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HDAC6 |
| Gene ID: |
10013 |
| Swiss Prot: |
Q9UBN7 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
H2B, H3 and H4), Histone deacetylases act via the formation of large multiprotein complexes (By similarity), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, In addition to its protein deacetylase activity, Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer, Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, cell cycle progression and developmental events, facilitating their clearance by autophagy, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0901 JM21 HD6 FLJ16239 PPP1R90 |
| Also known as: |
HDAC6 Polyclonal Antibody |
| Other name: |
Anti-HDAC6 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HDAC6 |
| Short name: |
Anti-HDAC6 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-histone deacetylase 6 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, CPBHM and HD6 and PPP1R90, DNA-templated and biological process this GO :0006476 and protein deacetylation and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006515 and misfolded or incompletely synthesized protein catabolic process and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0007026 and negative regulation of microtubule depolymerization and biological process this GO :0008013 and beta-catenin binding and molecular function this GO :0008017 and microtubule binding and molecular function this GO :0008152 and metabolic process and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009636 and response to toxic substance and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0010033 and response to organic substance and biological process this GO :0010469 and regulation of receptor activity and biological process this GO :0010634 and positive regulation of epithelial cell migration and biological process this GO :0010727 and negative regulation of hydrogen peroxide metabolic process and biological process this GO :0010870 and positive regulation of receptor biosynthetic process and biological process this GO :0016234 and inclusion body and cellular component this GO :0016235 and aggresome and cellular component this GO :0016236 and macroautophagy and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030286 and dynein complex and cellular component this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031252 and cell leading edge and cellular component this GO :0031593 and polyubiquitin binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032418 and lysosome localization and biological process this GO :0034983 and peptidyl-lysine deacetylation and biological process this GO :0035967 and cellular response to topologically incorrect protein and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0042903 and tubulin deacetylase activity and molecular function this GO :0043014 and alpha-tubulin binding and molecular function this GO :0043130 and ubiquitin binding and molecular function this GO :0043162 and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway and biological process this GO :0043204 and perikaryon and cellular component this GO :0043234 and protein complex and cellular component this GO :0043241 and protein complex disassembly and biological process this GO :0043242 and negative regulation of protein complex disassembly and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048156 and tau protein binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048487 and beta-tubulin binding and molecular function this GO :0051354 and negative regulation of oxidoreductase activity and biological process this GO :0051788 and response to misfolded protein and biological process this GO :0051879 and Hsp90 protein binding and molecular function this GO :0060632 and regulation of microtubule-based movement and biological process this GO :0060765 and regulation of androgen receptor signaling pathway and biological process this GO :0070201 and regulation of establishment of protein localization and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0070840 and dynein complex binding and molecular function this GO :0070842 and aggresome assembly and biological process this GO :0070845 and polyubiquitinated misfolded protein transport and biological process this GO :0070846 and Hsp90 deacetylation and biological process this GO :0070848 and response to growth factor and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0071218 and cellular response to misfolded protein and biological process this GO :0090035 and positive regulation of chaperone-mediated protein complex assembly and biological process this GO :0090042 and tubulin deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function this GO :1901300 and positive regulation of hydrogen peroxide-mediated programmed cell death and biological process, HDAC6 and IDBG-63929 and ENSG00000094631 and 10013, Hdac6 and IDBG-129835 and ENSMUSG00000031161 and 15185, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000209 and protein polyubiquitination and biological process this GO :0003779 and actin binding and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005874 and microtubule and cellular component this GO :0005875 and microtubule associated complex and cellular component this GO :0005881 and cytoplasmic microtubule and cellular component this GO :0005901 and caveola and cellular component this GO :0006351 and transcription, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0004407 : histone deacetylase activity and also this GO :0005515 : protein binding and also this GO :0008013 : beta-catenin binding and also this GO :0008017 : microtubule binding and also this GO :0008270 : zinc ion binding and also this GO :0016787 : hydrolase activity and also this GO :0019899 : enzyme binding and also this GO :0031593 : polyubiquitin binding and also this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0042826 : histone deacetylase binding and also this GO :0042903 : tubulin deacetylase activity and also this GO :0043014 : alpha-tubulin binding and also this GO :0043130 : ubiquitin binding and also this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0048156 : tau protein binding and also this GO :0048487 : beta-tubulin binding and also this GO :0051879 : Hsp90 protein binding and also this GO :0070840 : dynein complex binding and also this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0004407 : histone deacetylase activity, this GO :0005515 : protein binding, this GO :0008013 : beta-catenin binding, this GO :0008017 : microtubule binding, this GO :0008270 : zinc ion binding, this GO :0016787 : hydrolase activity, this GO :0019899 : enzyme binding, this GO :0031593 : polyubiquitin binding, this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0042826 : histone deacetylase binding, this GO :0042903 : tubulin deacetylase activity, this GO :0043014 : alpha-tubulin binding, this GO :0043130 : ubiquitin binding, this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0048156 : tau protein binding, this GO :0048487 : beta-tubulin binding, this GO :0051879 : Hsp90 protein binding, this GO :0070840 : dynein complex binding, this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), 76413 and IDBG-636881 and ENSBTAG00000013244 and 513602, histone deacetylase 6 |
| Identity: |
14064 |
| Gene: |
HDAC6 |
More about : HDAC6 |
| Long gene name: |
histone deacetylase 6 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 90 |
| Locus: |
Xp11, 23 |
| Discovery year: |
2000-11-28 |
| GenBank acession: |
AF132609 |
| Entrez gene record: |
10013 |
| Pubmed identfication: |
10220385 10048485 |
| RefSeq identity: |
NM_006044 |
| Classification: |
Histone deacetylases, class IIB Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000034496 |
| Locus Specific Databases: |
Mental Retardation database |