| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CRLF2 |
| Specificity: |
This antibody reacts specifically with CRLF2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CRLF2 |
| Gene ID: |
64109 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Expression has also been reported in heart, Ligand receptor interactions haves been implicated in the development of the hematopoietic system, STAT3 and STAT5 to stimulate cell proliferation, TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, TSLPR has a predicted molecular weight approximately 41 kD, The TSLP R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs, The TSLPR is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells, and kidney tissues, and the maintenance and polarization of human Th2 memory T cells in allergic diseases, and two further isoforms have been reported that are produced by alternative splicing, dendritic cell maturation, skeletal muscle, TSLPR is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CRL2 TSLPR |
| Also known as: |
CRLF2 Polyclonal Antibody |
| Other name: |
Anti-CRLF2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CRLF2 |
| Short name: |
Anti-CRLF2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-cytokine receptor-like factor 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CRLF2 and IDBG-39359 and ENSG00000205755 and 64109, CRLF2 and IDBG-645338 and ENSBTAG00000020242 and 529792, Crlf2 and IDBG-188983 and ENSMUSG00000033467 and 57914, Extracellular, protein binding, this GO :0002380 and immunoglobulin secretion involved in immune response and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0035745 and T-helper 2 cell cytokine production and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, cytokine receptor-like factor 2 |
| Identity: |
14281 |
| Gene: |
CRLF2 |
More about : CRLF2 |
| Long gene name: |
cytokine receptor-like factor 2 |
| Locus: |
Xp22, 3 , 3 and Yp11 |
| Discovery year: |
2001-02-06 |
| GenBank acession: |
AF142570 |
| Entrez gene record: |
64109 |
| Pubmed identfication: |
11237741 11474172 |
| RefSeq identity: |
NM_022148 |
| Classification: |
Fibronectin type III domain containing Pseudoautosomal region 1 |
| Havana BLAST/BLAT: |
OTTHUMG00000067432 |