| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IL5RA/CD125 |
| Specificity: |
This antibody reacts specifically with IL5RA/CD125 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IL-5R alpha |
| Gene ID: |
3568 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Six alternatively spliced transcript variants encoding three distinct isoforms have been reported, The beta subunit is activated by the ligand binding, The binding of this protein to IL5 depends on the beta subunit, The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3(IL3), This protein has been found to interact with syndecan binding protein (syntenin), and interleukin 5(IL5), and is required for the biological activities of IL5, colony stimulating factor 2 (CSF2/GM-CSF), which is required for IL5 mediated activation of the transcription factor SOX4, The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CDw125 CD125 |
| Also known as: |
IL5RA/CD125 Polyclonal Antibody |
| Other name: |
Anti-IL5RA/CD125 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IL5RA/CD125 |
| Short name: |
Anti-IL5RA/CD125 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, alpha/CD125 (polyclonal), antibody to-interleukin 5 receptor |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CD125 and CDw125 and HSIL5R3 and IL5R, Extracellular, IL5RA and IDBG-13590 and ENSG00000091181 and 3568, IL5RA and IDBG-644842 and ENSBTAG00000000273 and 615848, Il5ra and IDBG-173890 and ENSMUSG00000005364 and 16192, alpha, protein binding, this GO :0002437 and inflammatory response to antigenic stimulus and biological process this GO :0004896 and cytokine receptor activity and molecular function this GO :0004914 and interleukin-5 receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0008283 and cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0032674 and regulation of interleukin-5 production and biological process this GO :0038043 and interleukin-5-mediated signaling pathway and biological process this GO :0071310 and cellular response to organic substance and biological process, this GO :0004896 : cytokine receptor activity, this GO :0004896 : cytokine receptor activity and also this GO :0004914 : interleukin-5 receptor activity and also this GO :0005515 : protein binding, this GO :0004914 : interleukin-5 receptor activity, this GO :0005515 : protein binding, interleukin 5 receptor |
| Identity: |
6017 |
| Gene: |
IL5RA |
More about : IL5RA |
| Long gene name: |
interleukin 5 receptor subunit alpha |
| Synonyms gene: |
IL5R |
| Synonyms gene name: |
alpha , interleukin 5 receptor |
| Locus: |
3p26, 2 |
| Discovery year: |
1992-06-18 |
| GenBank acession: |
M96652 |
| Entrez gene record: |
3568 |
| Pubmed identfication: |
1732409 |
| Classification: |
CD molecules Interleukin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000090245 |