| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CCR5/CD195 |
| Specificity: |
This antibody reacts specifically with CCR5/CD195 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Helical, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CCR-5 |
| Gene ID: |
1234 |
| Swiss Prot: |
P51681 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level, May play a role in the control of granulocytic lineage proliferation or differentiation, Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CKR-5 CC-CKR-5 CKR5 CD195 IDDM22 |
| Also known as: |
CCR5/CD195 Polyclonal Antibody |
| Other name: |
Anti-CCR5/CD195 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CCR5/CD195 |
| Short name: |
Anti-CCR5/CD195 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-C motif) receptor 5 (gene/pseudogene)/CD195 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CC-CKR-5 and CCCKR5 and CCR-5 and CD195 and CKR-5 and CKR5 and CMKBR5 and IDDM22, CCR5 and IDBG-30229 and ENSG00000160791 and 1234, CCR5 and IDBG-646247 and ENSBTAG00000008099 and 497017, Cell surfaces, chemokine (C-C motif) ligand 5 binding, this GO :0000165 and MAPK cascade and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0003779 and actin binding and molecular function this GO :0004435 and phosphatidylinositol phospholipase C activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006816 and calcium ion transport and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0014808 and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum and biological process this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016493 and C-C chemokine receptor activity and molecular function this GO :0019722 and calcium-mediated signaling and biological process this GO :0019957 and C-C chemokine binding and molecular function this GO :0023052 and signaling and biological process this GO :0030260 and entry into host cell and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0070723 and response to cholesterol and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071791 and chemokine (C-C motif) ligand 5 binding and molecular function, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0004435 : phosphatidylinositol phospholipase C activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0016493 : C-C chemokine receptor activity and also this GO :0019957 : C-C chemokine binding and also this GO :0071791 : chemokine (C-C motif) ligand 5 binding, this GO :0004435 : phosphatidylinositol phospholipase C activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0005515 : protein binding, this GO :0015026 : coreceptor activity, this GO :0016493 : C-C chemokine receptor activity, this GO :0019957 : C-C chemokine binding, this GO :0071791 : chemokine (C-C motif) ligand 5 binding, chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| Identity: |
1606 |
| Gene: |
CCR5 |
More about : CCR5 |
| Long gene name: |
C-C motif chemokine receptor 5 (gene/pseudogene) |
| Synonyms gene: |
CMKBR5 |
| Synonyms gene name: |
chemokine (C-C motif) receptor 5 chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| Locus: |
3p21, 31 |
| Discovery year: |
1996-05-15 |
| Entrez gene record: |
1234 |
| Pubmed identfication: |
8639485 |
| RefSeq identity: |
NM_000579 |
| Classification: |
CD molecules C-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133481 |