| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TAP2/ABCB3 |
| Specificity: |
This antibody reacts specifically with TAP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TAP2 |
| Gene ID: |
389813 |
| Swiss Prot: |
C9J069 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is a heterodimer of TAP1 and TAP2, It is inhibited by human cytomegalovirus US6 glycoprotein, MDR subfamily, Nascent MHC class I molecules associate with TAP via tapasin, TAP also acts as a molecular scaffold for the final stage of MHC class I folding, TAP is inducible by interferon gamma and belongs to the ABC transporter family, TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2, namely the binding of peptide, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding, which blocks the peptide-binding site of TAP, TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TAP2 |
| Also known as: |
TAP2 Polyclonal Antibody |
| Other name: |
Anti-TAP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TAP2 |
| Short name: |
Anti-TAP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Uncharacterized protein (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ATPase activity, Plasma membranes, TAP-dependent and biological process this GO :0002485 and antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent and biological process this GO :0002489 and antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent and biological process this GO :0002504 and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and biological process this GO :0002591 and positive regulation of antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0005215 and transporter activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0006200 and ATP catabolic process and biological process this GO :0006810 and transport and biological process this GO :0006955 and immune response and biological process this GO :0015197 and peptide transporter activity and molecular function this GO :0015833 and peptide transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016887 and ATPase activity and molecular function this GO :0019882 and antigen processing and presentation and biological process this GO :0042613 and MHC class II protein complex and cellular component this GO :0042626 and ATPase activity, TAP2 and IDBG-403192 and ENSG00000250264 and, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances and molecular function this GO :0055085 and transmembrane transport and biological process, this GO :0002481 and antigen processing and presentation of exogenous protein antigen via MHC class Ib, this GO :0005215 : transporter activity, this GO :0005215 : transporter activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0015197 : peptide transporter activity and also this GO :0016887 : ATPase activity and also this GO :0042626 : ATPase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0015197 : peptide transporter activity, this GO :0016887 : ATPase activity, this GO :0042626 : ATPase activity, Uncharacterized protein |
| Identity: |
18655 |
| Gene: |
SEC14L3 |
More about : SEC14L3 |
| Long gene name: |
SEC14 like lipid binding 3 |
| Synonyms gene name: |
SEC14-like 3 (S, cerevisiae) SEC14-like lipid binding 3 |
| Synonyms name: |
tocopherol-associated protein 2 |
| Locus: |
22q12, 2 |
| Discovery year: |
2002-09-18 |
| GenBank acession: |
AY158086 |
| Entrez gene record: |
266629 |
| Pubmed identfication: |
12757856 15040456 17428729 |
| RefSeq identity: |
NM_174975 |
| Classification: |
SEC14 family |
| Havana BLAST/BLAT: |
OTTHUMG00000151259 |