| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GRM2+GRM4 |
| Specificity: |
This antibody reacts specifically with GRM2+GRM4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GRM2+GRM4 |
| Gene ID: |
2912 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
GRM6, GRM7 and GRM8, Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions, Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C, Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities, Group II includes GRM2 and GRM3 while Group III includes GRM4, The metabotropic glutamate receptors are a family of G protein coupled receptors, and pharmacologic properties, putative signal transduction mechanisms, that have been divided into 3 groups on the basis of sequence homology, L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GPRC1B mGlu2 MGLUR2 |
| Also known as: |
GRM2+GRM4 Polyclonal Antibody |
| Other name: |
Anti-GRM2+GRM4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GRM2+GRM4 |
| Short name: |
Anti-GRM2+GRM4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GRM2+GRM4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4594 |
| Gene: |
GRM2 |
More about : GRM2 |
| Long gene name: |
glutamate metabotropic receptor 2 |
| Synonyms gene name: |
glutamate receptor, metabotropic 2 |
| Locus: |
3p21, 2 |
| Discovery year: |
1993-10-21 |
| GenBank acession: |
L35318 |
| Entrez gene record: |
2912 |
| Pubmed identfication: |
7620613 |
| Classification: |
Glutamate metabotropic receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000156902 |