| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ABI1 |
| Specificity: |
This antibody reacts specifically with ABI1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ABI1 |
| Gene ID: |
10006 |
| Swiss Prot: |
Q8IZP0 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex, In brain, In vitro, Involved in cytoskeletal reorganization and EGFR signaling, May play a role in regulation of EGF-induced Erk pathway activation, Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level, Regulates ABL1/c-Abl-mediated phosphorylation of ENAH, Together with EPS8 participates in transduction of signals from Ras to Rac, a trimeric complex of ABI1, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons, May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
E3B1 ABI-1 |
| Also known as: |
ABI1 Polyclonal Antibody |
| Other name: |
Anti-ABI1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ABI1 |
| Short name: |
Anti-ABI1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ABI1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11320 |
| Gene: |
ABI1 |
More about : ABI1 |
| Long gene name: |
abl interactor 1 |
| Synonyms gene: |
SSH3BP1 |
| Synonyms gene name: |
spectrin SH3 domain binding protein 1 abl-interactor 1 |
| Locus: |
10p12, 1 |
| Discovery year: |
1999-05-17 |
| GenBank acession: |
U87166 |
| Entrez gene record: |
10006 |
| Pubmed identfication: |
9593709 9010225 |
| RefSeq identity: |
NM_005470 |
| Havana BLAST/BLAT: |
OTTHUMG00000017848 |