| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SLC6A4/5-HTT |
| Specificity: |
This antibody reacts specifically with SLC6A4/5-HTT |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human 5-HTT |
| Gene ID: |
6532 |
| Swiss Prot: |
P31645 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems, Terminates the action of serotonin and recycles it in a sodium-dependent manner, Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
5-HTT SERT1 |
| Also known as: |
SLC6A4/5-HTT Polyclonal Antibody |
| Other name: |
Anti-SLC6A4/5-HTT Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SLC6A4/5-HTT |
| Short name: |
Anti-SLC6A4/5-HTT (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SLC6A4/5-huntingtin (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
HD and IT15, HTT and IDBG-643549 and ENSBTAG00000001506 and 615059, HTT and IDBG-7852 and ENSG00000197386 and 3064, Htt and IDBG-156033 and ENSMUSG00000029104 and 15194, diazepam binding, nuclei, this GO :0000050 and urea cycle and biological process this GO :0000052 and citrulline metabolic process and biological process this GO :0000132 and establishment of mitotic spindle orientation and biological process this GO :0002039 and p53 binding and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005770 and late endosome and cellular component this GO :0005776 and autophagic vacuole and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006606 and protein import into nucleus and biological process this GO :0006839 and mitochondrial transport and biological process this GO :0006888 and ER to this GO lgi vesicle-mediated transport and biological process this GO :0006890 and retrograde vesicle-mediated transport, this GO :0002039 : p53 binding, this GO :0002039 : p53 binding and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0034452 : dynactin binding and also this GO :0042802 : identical protein binding and also this GO :0045505 : dynein intermediate chain binding and also this GO :0048487 : beta-tubulin binding and also this GO :0050809 : diazepam binding, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0034452 : dynactin binding, this GO :0042802 : identical protein binding, this GO :0045505 : dynein intermediate chain binding, this GO :0048487 : beta-tubulin binding, this GO :0050809 : diazepam binding, this GO lgi to ER and biological process this GO :0006915 and apoptotic process and biological process this GO :0007005 and mitochondrion organization and biological process this GO :0007029 and endoplasmic reticulum organization and biological process this GO :0007030 and this GO lgi organization and biological process this GO :0007212 and dopamine receptor signaling pathway and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007369 and gastrulation and biological process this GO :0007417 and central nervous system development and biological process this GO :0007420 and brain development and biological process this GO :0007569 and cell aging and biological process this GO :0007611 and learning or memory and biological process this GO :0007612 and learning and biological process this GO :0007625 and grooming behavior and biological process this GO :0007626 and locomotory behavior and biological process this GO :0008088 and axon car this GO transport and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008306 and associative learning and biological process this GO :0008340 and determination of adult lifespan and biological process this GO :0008542 and visual learning and biological process this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016197 and endosomal transport and biological process this GO :0016234 and inclusion body and cellular component this GO :0019244 and lactate biosynthetic process from pyruvate and biological process this GO :0019805 and quinolinate biosynthetic process and biological process this GO :0021756 and striatum development and biological process this GO :0021988 and olfactory lobe development and biological process this GO :0021990 and neural plate formation and biological process this GO :0022008 and neurogenesis and biological process this GO :0030072 and peptide hormone secretion and biological process this GO :0030073 and insulin secretion and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0034047 and regulation of protein phosphatase type 2A activity and biological process this GO :0034452 and dynactin binding and molecular function this GO :0035176 and social behavior and biological process this GO :0042445 and hormone metabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045505 and dynein intermediate chain binding and molecular function this GO :0046902 and regulation of mitochondrial membrane permeability and biological process this GO :0047496 and vesicle transport along microtubule and biological process this GO :0048167 and regulation of synaptic plasticity and biological process this GO :0048341 and paraxial mesoderm formation and biological process this GO :0048487 and beta-tubulin binding and molecular function this GO :0048513 and organ development and biological process this GO :0048666 and neuron development and biological process this GO :0050809 and diazepam binding and molecular function this GO :0051402 and neuron apoptotic process and biological process this GO :0051592 and response to calcium ion and biological process this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0051938 and L-glutamate import and biological process this GO :0055072 and iron ion homeostasis and biological process this GO :1901215 and negative regulation of neuron death and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process, huntingtin |
| Identity: |
11050 |
| Gene: |
SLC6A4 |
More about : SLC6A4 |
| Long gene name: |
solute carrier family 6 member 4 |
| Synonyms gene: |
HTT OCD1 |
| Synonyms gene name: |
member 4 , member 4 5-hydroxytryptamine (serotonin) transporter obsessive-compulsive disorder 1 solute carrier family 6 (neurotransmitter transporter), serotonin), solute carrier family 6 (neurotransmitter transporter |
| Synonyms name: |
serotonin transporter 1 |
| Locus: |
17q11, 2 |
| Discovery year: |
1994-03-16 |
| GenBank acession: |
L05568 |
| Entrez gene record: |
6532 |
| Pubmed identfication: |
7681602 19806148 |
| RefSeq identity: |
NM_001045 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000132751 |