| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
5HTR2B/HTR2B |
| Specificity: |
This antibody reacts specifically with 5HTR2B/HTR2B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human 5HTR2B |
| Gene ID: |
3357 |
| Swiss Prot: |
P41595 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances, Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, May play a role in the perception of pain, Plays a role in the adaptation of pulmonary arteries to chronic hypoxia, Plays a role in the regulation of behavior, Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, Plays a role in vasoconstriction, Protects cardiomyocytes against apoptosis, Required for normal osteoblast function and proliferation, Required for normal proliferation of embryonic cardiac myocytes and normal heart development, Required for normal proliferation of the interstitial cells of Cajal in the intestine, Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores, and for maintaining normal bone density, and thereby affects neural activity, including impulsive behavior, G-protein coupled receptor for 5-hydroxytryptamine (serotonin) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
5-HT(2B), 5-HT-2B, 5-hydroxytryptamine receptor 2B, HTR2B, Serotonin receptor 2B, 5-HT2B |
| Also known as: |
5HTR2B/HTR2B Polyclonal Antibody |
| Other name: |
Anti-5HTR2B/HTR2B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
5HTR2B/HTR2B |
| Short name: |
Anti-5HTR2B/HTR2B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, G protein-coupled (polyclonal), antibody to-5HTR2B-hydroxytryptamine (serotonin) receptor 2B |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
5-HT(2B) and 5-HT2B, 5HTR2B and IDBG-644379 and ENSBTAG00000039772 and 407135, Cell surfaces, G protein-coupled, HTR2B and IDBG-83044 and ENSG00000135914 and 3357, Htr2b and IDBG-176588 and ENSMUSG00000026228 and 15559, serotonin binding, this GO :0001755 and neural crest cell migration and biological process this GO :0001819 and positive regulation of cytokine production and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001965 and G-protein alpha-subunit binding and molecular function this GO :0002031 and G-protein coupled receptor internalization and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003300 and cardiac muscle hypertrophy and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004993 and serotonin receptor activity and molecular function this GO :0005099 and Ras GTPase activator activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006182 and cGMP biosynthetic process and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007202 and activation of phospholipase C activity and biological process this GO :0007205 and protein kinase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007210 and serotonin receptor signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0007610 and behavior and biological process this GO :0008144 and drug binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0010507 and negative regulation of autophagy and biological process this GO :0010513 and positive regulation of phosphatidylinositol biosynthetic process and biological process this GO :0014033 and neural crest cell differentiation and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0014827 and intestine smooth muscle contraction and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016310 and phosphorylation and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0030054 and cell junction and cellular component this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0042310 and vasoconstriction and biological process this GO :0042493 and response to drug and biological process this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0045202 and synapse and cellular component this GO :0048598 and embryonic morphogenesis and biological process this GO :0050715 and positive regulation of cytokine secretion and biological process this GO :0050795 and regulation of behavior and biological process this GO :0051000 and positive regulation of nitric-oxide synthase activity and biological process this GO :0051209 and release of sequestered calcium ion into cytosol and biological process this GO :0051378 and serotonin binding and molecular function this GO :0051781 and positive regulation of cell division and biological process this GO :0060548 and negative regulation of cell death and biological process this GO :0070371 and ERK1 and ERK2 cascade and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070528 and protein kinase C signaling and biological process this GO :0071502 and cellular response to temperature stimulus and biological process, this GO :0001965 : G-protein alpha-subunit binding, this GO :0001965 : G-protein alpha-subunit binding and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004993 : serotonin receptor activity and also this GO :0005099 : Ras GTPase activator activity and also this GO :0008144 : drug binding and also this GO :0051378 : serotonin binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0004993 : serotonin receptor activity, this GO :0005099 : Ras GTPase activator activity, this GO :0008144 : drug binding, this GO :0051378 : serotonin binding, 5-hydroxytryptamine (serotonin) receptor 2B |