| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
COMT |
| Specificity: |
This antibody reacts specifically with COMT |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human COMT |
| Gene ID: |
1312 |
| Swiss Prot: |
P21964 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also shortens the biological half-lives of certain neuroactive drugs, alpha-methyl DOPA and isoproterenol, and thereby the inactivation, like L-DOPA, of catecholamine neurotransmitters and catechol hormones, Catalyzes the O-methylation |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
COMT Polyclonal Antibody |
| Other name: |
Anti-COMT Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
COMT |
| Short name: |
Anti-COMT (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-catechol-O-methyltransferase (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
COMT and IDBG-1506 and ENSG00000093010 and 1312, COMT and IDBG-638156 and ENSBTAG00000019516 and 618278, Comt and IDBG-141739 and ENSMUSG00000000326 and 12846, HEL-S-98n, Plasma membranes, catechol O-methyltransferase activity, this GO :0000287 and magnesium ion binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006584 and catecholamine metabolic process and biological process this GO :0006805 and xenobiotic metabolic process and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007565 and female pregnancy and biological process this GO :0007612 and learning and biological process this GO :0007614 and short-term memory and biological process this GO :0008171 and O-methyltransferase activity and molecular function this GO :0008210 and estrogen metabolic process and biological process this GO :0009712 and catechol-containing compound metabolic process and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016036 and cellular response to phosphate starvation and biological process this GO :0016206 and catechol O-methyltransferase activity and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0032259 and methylation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032502 and developmental process and biological process this GO :0035814 and negative regulation of renal sodium excretion and biological process this GO :0042135 and neurotransmitter catabolic process and biological process this GO :0042136 and neurotransmitter biosynthetic process and biological process this GO :0042417 and dopamine metabolic process and biological process this GO :0042420 and dopamine catabolic process and biological process this GO :0042493 and response to drug and biological process this GO :0043197 and dendritic spine and cellular component this GO :0044281 and small molecule metabolic process and biological process this GO :0044297 and cell body and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0045963 and negative regulation of dopamine metabolic process and biological process this GO :0048265 and response to pain and biological process this GO :0048609 and multicellular organismal reproductive process and biological process this GO :0048662 and negative regulation of smooth muscle cell proliferation and biological process this GO :0050668 and positive regulation of homocysteine metabolic process and biological process this GO :0051930 and regulation of sensory perception of pain and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0008171 : O-methyltransferase activity and also this GO :0016206 : catechol O-methyltransferase activity, this GO :0008171 : O-methyltransferase activity, this GO :0016206 : catechol O-methyltransferase activity, catechol-O-methyltransferase |
| Identity: |
2228 |
| Gene: |
COMT |
More about : COMT |
| Long gene name: |
catechol-O-methyltransferase |
| Locus: |
22q11, 21 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
1312 |
| Pubmed identfication: |
1572656 |
| RefSeq identity: |
NM_000754 |
| Havana BLAST/BLAT: |
OTTHUMG00000150529 |
| Locus Specific Databases: |
LRG_1010 |