| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
C1s |
| Specificity: |
This antibody reacts specifically with C1s |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human C1s |
| Gene ID: |
716 |
| Swiss Prot: |
P09871 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activated C1s is in the form of a disulfide-linked heterodimer consisting of a heavy chain and a light chain, Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, C1, C1 consists of a calcium dependent trimolecular complex of C1r, C1q, C1s and C1q in a 2:2:1 ratio, C3, C4, Defects in the gene encoding for C1s can cause selective C1s deficiency, a disorder characterized by early onset of various autoimmune diseases, and C5, and cellular chemotaxis, arachidonic acid metabolism, are potent anaphylatoxins that are released during complement activation, cytokine release, leukocyte activation, smooth muscle contraction, such as cellular degranulation, the first component of the classical pathway of the serum complement system, together with proenzymes C1r and C1s, yield C1, The complement component proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
C1s Polyclonal Antibody |
| Other name: |
Anti-C1s Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
C1s |
| Short name: |
Anti-C1s (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, s subcomponent (polyclonal), antibody to-complement component 1 |
| Alternative technique: |
polyclonals |
| Identity: |
1247 |
| Gene: |
C1S |
More about : C1S |
| Long gene name: |
complement C1s |
| Synonyms gene name: |
complement component 1, s subcomponent |
| Locus: |
12p13, 31 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
716 |
| RefSeq identity: |
NM_001734 |
| Classification: |
Sushi domain containing Complement system |
| Havana BLAST/BLAT: |
OTTHUMG00000150305 |
| Locus Specific Databases: |
C1Sbase: Mutation registry for C1s deficiency LRG_25 |