| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
I16/MNDA |
| Specificity: |
This antibody reacts specifically with IFI16/MNDA |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IFI16 |
| Gene ID: |
3428 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
All are phosphorylated on serine and threonine residues and can homo and heterodimerize, B, Due to its localization in the nucleus, Expression is restricted to the nuclei of hematopoietic cells, IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell, IFI16 has three isotypes A, IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain, In addition, and C (85-95 kDa), and ability to bind DNA, fibroblasts and epithelial cells, it is assumed that IFI16 has a role in transcription regulation of cell differentiation, it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells, regulation of protein expression, transcriptional regulatory domain and DAPIN/PAAD domain, which arise as a result of mRNA alternative splicing, Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IFNGIP1 PYHIN2 |
| Also known as: |
IFI16/MNDA Polyclonal Antibody |
| Other name: |
Anti-IFI16/MNDA Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IFI16/MNDA |
| Short name: |
Anti-IFI16/MNDA (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, gamma-inducible protein 16/myeloid cell nuclear differentiation antigen (polyclonal), antibody to-interferon |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006914 and autophagy and biological process this GO :0006954 and inflammatory response and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0010506 and regulation of autophagy and biological process this GO :0016020 and membrane and cellular component this GO :0016607 and nuclear speck and cellular component this GO :0030097 and hemopoiesis and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030224 and monocyte differentiation and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032731 and positive regulation of interleukin-1 beta production and biological process this GO :0042149 and cellular response to glucose starvation and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043392 and negative regulation of DNA binding and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045071 and negative regulation of viral genome replication and biological process this GO :0045087 and innate immune response and biological process this GO :0045824 and negative regulation of innate immune response and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0006968 and cellular defense response and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0030889 and negative regulation of B cell proliferation and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0051607 and defense response to virus and biological process this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0072332 and intrinsic apoptotic signaling pathway by p53 class mediator and biological process this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :2000117 and negative regulation of cysteine-type endopeptidase activity and biological process, IFI16 and IDBG-103852 and ENSG00000163565 and 3428, IFNGIP1 and PYHIN2, MNDA and IDBG-103838 and ENSG00000163563 and 4332, PYHIN3, gamma-inducible protein 16, interferon, nuclei, nuclei, poly(A) RNA binding, protein binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001819 and positive regulation of cytokine production and biological process this GO :0002218 and activation of innate immune response and biological process this GO :0003690 and double-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0005515 : protein binding, this GO :0003690 : double-stranded DNA binding, this GO :0003690 : double-stranded DNA binding and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0044822 : poly(A) RNA binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0044822 : poly(A) RNA binding, myeloid cell nuclear differentiation antigen |
| Identity: |
5395 |
| Gene: |
IFI16 |
More about : IFI16 |
| Long gene name: |
interferon gamma inducible protein 16 |
| Locus: |
1q23, 1 |
| Discovery year: |
1993-09-29 |
| GenBank acession: |
M63838 |
| Entrez gene record: |
3428 |
| Pubmed identfication: |
1526658 7959953 |
| RefSeq identity: |
NM_005531 |
| Classification: |
Pyrin domain containing Pyrin and HIN domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000037108 |