| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TERT |
| Specificity: |
This antibody reacts specifically with TERT |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TERT |
| Gene ID: |
7015 |
| Swiss Prot: |
O14746 |
| Applications: |
IF(ICC), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
5'-TTAGGG-3', Active in progenitor and cancer cells, Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme, Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, Inactive, Modulates Wnt signaling, More active on substrates containing 2 or 3 telomeric repeats, Plays important roles in aging and antiapoptosis, Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, The catalytic cycle involves primer binding, chaperones and polypeptide modifiers, in normal somatic cells, or very low activity, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension, Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TRT TP2 TCS1 hEST2 EST2 |
| Also known as: |
TERT Polyclonal Antibody |
| Other name: |
Anti-TERT Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TERT |
| Short name: |
Anti-TERT (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-telomerase reverse transcriptase (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, CMM9 and DKCA2 and DKCB4 and EST2 and hEST2 and hTRT and PFBMFT1 and TCS1 and TP2 and TRT, TERT and IDBG-10998 and ENSG00000164362 and 7015, Tert and IDBG-165912 and ENSMUSG00000021611 and 21752, nuclei, telomeric RNA binding, telomeric region and cellular component this GO :0000783 and nuclear telomere cap complex and cellular component this GO :0003720 and telomerase activity and molecular function this GO :0003721 and telomeric template RNA reverse transcriptase activity and molecular function this GO :0003964 and RNA-directed DNA polymerase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005697 and telomerase holoenzyme complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007004 and telomere maintenance via telomerase and biological process this GO :0016605 and PML body and cellular component this GO :0022616 and DNA strand elongation and biological process this GO :0032203 and telomere formation via telomerase and biological process this GO :0042162 and telomeric DNA binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0070034 and telomeric RNA binding and molecular function this GO :0090399 and replicative senescence and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0000723 and telomere maintenance and biological process this GO :0000781 and chromosome, this GO :0003720 : telomerase activity, this GO :0003720 : telomerase activity and also this GO :0003721 : telomeric template RNA reverse transcriptase activity and also this GO :0003964 : RNA-directed DNA polymerase activity and also this GO :0005515 : protein binding and also this GO :0042162 : telomeric DNA binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046872 : metal ion binding and also this GO :0070034 : telomeric RNA binding, this GO :0003721 : telomeric template RNA reverse transcriptase activity, this GO :0003964 : RNA-directed DNA polymerase activity, this GO :0005515 : protein binding, this GO :0042162 : telomeric DNA binding, this GO :0042803 : protein homodimerization activity, this GO :0046872 : metal ion binding, this GO :0070034 : telomeric RNA binding, 60929 and IDBG-632169 and ENSBTAG00000012567 and 518884, telomerase reverse transcriptase |
| Identity: |
11730 |
| Gene: |
TERT |
More about : TERT |
| Long gene name: |
telomerase reverse transcriptase |
| Locus: |
5p15, 33 |
| Discovery year: |
1998-01-21 |
| GenBank acession: |
AF015950 |
| Pubmed identfication: |
9252327 |
| Havana BLAST/BLAT: |
OTTHUMG00000090357 |
| Locus Specific Databases: |
LRG_343 |