| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PCDHB12 |
| Specificity: |
This antibody reacts specifically with PCDHB12 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PCDHB12 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
As a result, Localized to the cell membrane, PCDHB12 (Protocadherin beta 12) is a 795 amino acid protein that is one of 16 proteins in the protocadherin beta cluster, PCDHB12 is a single-pass type I membrane protein that contains six cadherin domains, PCDHB12 may participate in the establishment and maintenance of specific neuronal connections in the brain, There are three protocadherin gene clusters, Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, all of which contain multiple tandemly arranged genes, beta and gamma, designated alpha, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein, members of the beta cluster (such as PCDHB12) do not use constant-region exons to produce mRNAs, Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PCDH-BETA12 |
| Also known as: |
PCDHB12 Polyclonal Antibody |
| Other name: |
Anti-PCDHB12 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PCDHB12 |
| Short name: |
Anti-PCDHB12 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-protocadherin b 12 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
PCDHB12 and IDBG-50135 and ENSG00000120328 and 56124, Plasma membranes, calcium ion binding, this GO :0005509 and calcium ion binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007156 and homophilic cell adhesion and biological process this GO :0007399 and nervous system development and biological process this GO :0016020 and membrane and cellular component, this GO :0005509 : calcium ion binding, this GO :0005509 : calcium ion binding, protocadherin beta 12 |
| Identity: |
8683 |
| Gene: |
PCDHB12 |
More about : PCDHB12 |
| Long gene name: |
protocadherin beta 12 |
| Locus: |
5q31, 3 |
| Discovery year: |
2000-06-28 |
| GenBank acession: |
AF152491 |
| Entrez gene record: |
56124 |
| Pubmed identfication: |
10380929 |
| RefSeq identity: |
NM_018932 |
| Classification: |
Clustered protocadherins |
| Havana BLAST/BLAT: |
OTTHUMG00000129620 |