| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PR3 |
| Specificity: |
This antibody reacts specifically with PR3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PR3 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation, It is closely related to two others: Neutrophil Elastase and azurocidin, P29 or myeloblastin), PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells, PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth, The antigen responsible for this disease is Proteinase 3 (PR3, The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19, necrotizing glomerulonephritis and pulmonary capillaritis, which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family, which most often affect the upper and lower airways and are associated with vasculitis, The major features of Wegener granulomatosis are necrotizing granulomatous lesions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AGP 7, AGP7, AGP7 serine proteinase, Azurophil Granule Protein 7, C ANCA antigen, C-ANCA antigen, EC 3, Leukocyte proteinase 3, MBN, MBT WEGENER AUTOANTIGEN, Myeloblastin, NP 4, NP-4, NP4, Neutrophil proteinase 4, P29, PR 3, PR-3, PR3, PRTN 3, PRTN3_HUMAN, Proteinase3, Prtn3, Serine proteinase neutrophil Wegener granulomatosis autoantigen, Wegener autoantigen, 4, 21, 76, ACPA |
| Also known as: |
PR3 Polyclonal Antibody |
| Other name: |
Anti-PR3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PR3 |
| Short name: |
Anti-PR3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PR3 (polyclonal) |
| Alternative technique: |
polyclonals |