| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ATM |
| Specificity: |
This antibody reacts specifically with ATM |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse ATM |
| Gene ID: |
11920 |
| Swiss Prot: |
Q62388 |
| Applications: |
IF(ICC), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, Also involved in signal transduction and cell cycle control, Also plays a role in pre-B cell allelic exclusion, BRCA1, Binds DNA ends, CHEK2, CTIP, Could play a role in T-cell development, FANCD2, May function as a tumor suppressor, May play a role in vesicle and/or protein transport, NFKBIA, Necessary for activation of ABL1 and SAPK, Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), Phosphorylates ATF2 which stimulates its function in DNA damage response, Phosphorylates DYRK2, Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation, Plays a role in replication-dependent histone mRNA degradation, RAD9 and DCLRE1C, Recognizes the substrate consensus sequence [ST]-Q, TERF1, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), gonad and neurological function, nibrin (NBN), p53/TP53, preventing accessibility to the RAG complex and recombination of the second allele, thereby acting as a DNA damage sensor, thereby regulating DNA damage response mechanism, Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TEL1 TELO1 |
| Also known as: |
ATM Polyclonal Antibody |
| Other name: |
Anti-ATM Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ATM |
| Short name: |
Anti-ATM (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ataxia telangiectasia mutated (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824, ATM and IDBG-70193 and ENSG00000149311 and 472, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, alcohol group as acceptor, alcohol group as acceptor and also this GO :0032403 : protein complex binding and also this GO :0035174 : histone serine kinase activity and also this GO :0046983 : protein dimerization activity and also this GO :0047485 : protein N-terminus binding, alcohol group as acceptor and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030889 and negative regulation of B cell proliferation and biological process this GO :0032403 and protein complex binding and molecular function this GO :0035174 and histone serine kinase activity and molecular function this GO :0035404 and histone-serine phosphorylation and biological process this GO :0036092 and phosphatidylinositol-3-phosphate biosynthetic process and biological process this GO :0042159 and lipoprotein catabolic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043517 and positive regulation of DNA damage response, nuclei, signal transduction by p53 class mediator and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0047485 and protein N-terminus binding and molecular function this GO :0048599 and oocyte development and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0071044 and histone mRNA catabolic process and biological process this GO :0071480 and cellular response to gamma radiation and biological process this GO :0072434 and signal transduction involved in mitotic G2 DNA damage checkpoint and biological process this GO :0090399 and replicative senescence and biological process, signal transduction by p53 class mediator resulting in cell cycle arrest and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007094 and mitotic spindle assembly checkpoint and biological process this GO :0007131 and reciprocal meiotic recombination and biological process this GO :0007165 and signal transduction and biological process this GO :0007292 and female gamete generation and biological process this GO :0007420 and brain development and biological process this GO :0007507 and heart development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016303 and 1-phosphatidylinositol-3-kinase activity and molecular function this GO :0016572 and histone phosphorylation and biological process this GO :0016772 and transferase activity, telomeric region and cellular component this GO :0001666 and response to hypoxia and biological process this GO :0001756 and somitogenesis and biological process this GO :0002331 and pre-B cell allelic exclusion and biological process this GO :0003677 and DNA binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004677 and DNA-dependent protein kinase activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005819 and spindle and cellular component this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006975 and DNA damage induced protein phosphorylation and biological process this GO :0006977 and DNA damage response, this GO :0000077 and DNA damage checkpoint and biological process this GO :0000723 and telomere maintenance and biological process this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000781 and chromosome, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004677 : DNA-dependent protein kinase activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016303 : 1-phosphatidylinositol-3-kinase activity and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004677 : DNA-dependent protein kinase activity, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016303 : 1-phosphatidylinositol-3-kinase activity, this GO :0016772 : transferase activity, this GO :0016773 : phosphotransferase activity, this GO :0032403 : protein complex binding, this GO :0035174 : histone serine kinase activity, this GO :0046983 : protein dimerization activity, this GO :0047485 : protein N-terminus binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773 : phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, ataxia telangiectasia mutated |
| Identity: |
795 |
| Gene: |
ATM |
More about : ATM |
| Long gene name: |
ATM serine/threonine kinase |
| Synonyms gene: |
ATA ATDC ATC ATD |
| Synonyms gene name: |
C and D) ataxia telangiectasia mutated , ataxia telangiectasia mutated (includes complementation groups A |
| Synonyms name: |
TEL1, cerevisiae) , homolog (S, telomere maintenance 1 |
| Locus: |
11q22, 3 |
| Discovery year: |
1995-07-07 |
| GenBank acession: |
AB209133 |
| Entrez gene record: |
472 |
| RefSeq identity: |
NM_000051 |
| Havana BLAST/BLAT: |
OTTHUMG00000166480 |
| Locus Specific Databases: |
Ataxia Telangiectasia Mutated (ATM) LOVD - Leiden Open Variation Database LRG_135 |