| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
KAT5 / Tip60 |
| Specificity: |
This antibody reacts specifically with KAT5 / Tip60 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human KAT5 / Tip60 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additional MOZ related proteins, MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins, These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation, estrogen and progesterone receptors, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation, MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TIP60 PLIP cPLA2 HTATIP1 ESA1 ZC2HC5 |
| Also known as: |
KAT5 / Tip60 Polyclonal Antibody |
| Other name: |
Anti-KAT5 / Tip60 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
KAT5 / Tip60 |
| Short name: |
Anti-KAT5 / Tip60 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-K(lysine) acetyltransferase 5 / Tip60 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006978 and DNA damage response, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050681 and androgen receptor binding and molecular function this GO :0070491 and repressing transcription factor binding and molecular function this GO :0071392 and cellular response to estradiol stimulus and biological process, KAT5 and IDBG-57604 and ENSG00000172977 and 10524, KAT5 and IDBG-644226 and ENSBTAG00000005578 and 505619, Kat5 and IDBG-132192 and ENSMUSG00000024926 and 81601, cPLA2 and ESA1 and HTATIP and HTATIP1 and PLIP and TIP and TIP60 and ZC2HC5, nuclei, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0010212 and response to ionizing radiation and biological process this GO :0016032 and viral process and biological process this GO :0016573 and histone acetylation and biological process this GO :0016747 and transferase activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000785 and chromatin and cellular component this GO :0000812 and Swr1 complex and cellular component this GO :0003713 and transcription coactivator activity and molecular function this GO :0004402 and histone acetyltransferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006302 and double-strand break repair and biological process this GO :0006325 and chromatin organization and biological process this GO :0006351 and transcription, this GO :0003713 : transcription coactivator activity, this GO :0003713 : transcription coactivator activity and also this GO :0004402 : histone acetyltransferase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0016747 : transferase activity, this GO :0004402 : histone acetyltransferase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0016747 : transferase activity, this GO :0032403 : protein complex binding, this GO :0046872 : metal ion binding, this GO :0050681 : androgen receptor binding, this GO :0070491 : repressing transcription factor binding, transferase activity, transferring acyl groups other than amino-acyl groups, transferring acyl groups other than amino-acyl groups and also this GO :0032403 : protein complex binding and also this GO :0046872 : metal ion binding and also this GO :0050681 : androgen receptor binding and also this GO :0070491 : repressing transcription factor binding, transferring acyl groups other than amino-acyl groups and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0032777 and Piccolo NuA4 histone acetyltransferase complex and cellular component this GO :0035267 and NuA4 histone acetyltransferase complex and cellular component this GO :0040008 and regulation of growth and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0043234 and protein complex and cellular component this GO :0045892 and negative regulation of transcription, K(lysine) acetyltransferase 5 |
| Identity: |
5275 |
| Gene: |
KAT5 |
More about : KAT5 |
| Long gene name: |
lysine acetyltransferase 5 |
| Synonyms gene: |
HTATIP |
| Synonyms gene name: |
60kDa K(lysine) acetyltransferase 5 , HIV-1 Tat interactive protein |
| Synonyms name: |
60kDa K-acetyltransferase 5 , Tat interacting protein |
| Locus: |
11q13, 1 |
| Discovery year: |
2000-04-13 |
| GenBank acession: |
U74667 |
| Entrez gene record: |
10524 |
| Pubmed identfication: |
8607265 |
| RefSeq identity: |
NM_006388 |
| Classification: |
Lysine acetyltransferases Zinc fingers C2HC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000166617 |