| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MCL1 |
| Specificity: |
This antibody reacts specifically with MCL1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Helical |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MCL1 |
| Gene ID: |
4170 |
| Swiss Prot: |
Q07820 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Isoform 1 inhibits apoptosis, Isoform 2 promotes apoptosis, Mediates its effects by interactions with a number of other regulators of apoptosis, and in the maintenance of viability but not of proliferation, Involved in the regulation of apoptosis versus cell survival |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BCL2L3 Mcl-1 |
| Also known as: |
MCL1 Polyclonal Antibody |
| Other name: |
Anti-MCL1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MCL1 |
| Short name: |
Anti-MCL1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-myeloid cell leukemia sequence 1 (BCL2-related) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BH3 domain binding, MCL1 and IDBG-102145 and ENSG00000143384 and 4170, Mcl1 and IDBG-173221 and ENSMUSG00000038612 and 17210, bcl2-L-3 and BCL2L3 and EAT and Mcl-1 and MCL1-ES and mcl1/EAT and MCL1L and MCL1S and TM, nuclei, this GO :0001709 and cell fate determination and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0015266 and protein channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019725 and cellular homeostasis and biological process this GO :0034097 and response to cytokine and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051434 and BH3 domain binding and molecular function this GO :0071806 and protein transmembrane transport and biological process this GO :0097136 and Bcl-2 family protein complex and cellular component this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001020 and regulation of response to DNA damage stimulus and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0015266 : protein channel activity and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051434 : BH3 domain binding, this GO :0015266 : protein channel activity, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051434 : BH3 domain binding, myeloid cell leukemia sequence 1 (BCL2-related) |
| Identity: |
6943 |
| Gene: |
MCL1 |
More about : MCL1 |
| Long gene name: |
BCL2 family apoptosis regulator |
| Synonyms gene name: |
myeloid cell leukemia sequence 1 (BCL2-related) myeloid cell leukemia 1 |
| Locus: |
1q21, 2 |
| Discovery year: |
1993-11-09 |
| GenBank acession: |
BC017197 |
| Entrez gene record: |
4170 |
| Pubmed identfication: |
7682708 7835896 |
| RefSeq identity: |
NM_021960 |
| Classification: |
BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000034867 |