| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PDE4D |
| Specificity: |
This antibody reacts specifically with PDE4D |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PDE4D |
| Gene ID: |
5144 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
D2, D3, D4 and D5), In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities, One or more PDE4D subtype variants are ubiquitously present in all mammalian cells, Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins, PDE4D1/D2 mRNA levels rise in response to an increase in cAMP, Peripheral tissues also exhibit differential expression of PDE4D variants, Short term regulation of PDE4D variants involved PKA, Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
PDE4D Polyclonal Antibody |
| Other name: |
Anti-PDE4D Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PDE4D |
| Short name: |
Anti-PDE4D (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PDE4D (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
8783 |
| Gene: |
PDE4D |
More about : PDE4D |
| Long gene name: |
phosphodiesterase 4D |
| Synonyms gene: |
DPDE3 |
| Synonyms gene name: |
cAMP-specific , cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3) phosphodiesterase 4D, phosphodiesterase 4D |
| Synonyms name: |
phosphodiesterase E3 dunce homolog (Drosophila) |
| Locus: |
5q11, 1 , 2-q12 |
| Discovery year: |
1992-06-08 |
| Entrez gene record: |
5144 |
| Classification: |
Phosphodiesterases |
| Havana BLAST/BLAT: |
OTTHUMG00000162218 |