| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Reticulon 4 |
| Specificity: |
Nogo-B, and Nogo-C), Based on the location of the target sequence this antibody will recognize all isoforms(Nogo-A, Reticulon 4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from Mouse Reticulon 4 |
| Gene ID: |
68585 |
| Swiss Prot: |
Q99P72 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, Involved in down-regulation of growth, It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex, May inhibit BACE1 activity and amyloid precursor protein processing, Reticulon 4 regulates neurite fasciculation, The reticulon protein is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells, and as a facilitator of neurite branching, branching and extension in the developing nervous system, stabilization of wiring and restriction of plasticity in the adult CNS, Reticulons are associated with the endoplasmic reticulum |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NOGOR |
| Also known as: |
Reticulon 4 Polyclonal Antibody |
| Other name: |
Anti-Reticulon 4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Reticulon 4 |
| Short name: |
Anti-Reticulon 4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Reticulon 4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18601 |
| Gene: |
RTN4R |
More about : RTN4R |
| Long gene name: |
reticulon 4 receptor |
| Locus: |
22q11, 21 |
| Discovery year: |
2002-04-30 |
| GenBank acession: |
AF283463 |
| Entrez gene record: |
65078 |
| Pubmed identfication: |
11201742 |
| Havana BLAST/BLAT: |
OTTHUMG00000150572 |