| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Exonuclease 1 |
| Specificity: |
This antibody reacts specifically with Exonuclease 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Exonuclease 1 |
| Gene ID: |
9156 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Exo1 interacts with MSH2 and MLH1 and has been proposed to be a redundant exonuclease in MMR, Exo1 is a 5'-3' double stranded DNA exonuclease that has previously been implicated in DNA mismatch repair (MMR), Exo1 is expressed prominently in testis, Exo1 plays a structural role in MMR and stabilizes multiprotein complexes containing a number of MMR proteins, In both mammalian and yeast systems, In both mammalian and yeast systems, In humans, In mice, The MMR system ensures genome integrity by removing mispaired and unpaired bases that originate during replication, a prominent lymphoid tissue, an area of active homologous recombination, and spleen, combined with previous biochemical and yeast genetic studies, consistent with the recent mapping of the orthologous human HEX1/EXO1 gene to chromosome 1q43, indicate that the Exo1 (Exonuclease I) proteins are important contributors to chromosome processing during mammalian DNA repair and recombination, the Exo1 gene maps to distal chromosome 1, Comparative evaluation of the expression patterns of the human and mouse genes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MGC33637 |
| Also known as: |
Exonuclease 1 Polyclonal Antibody |
| Other name: |
Anti-Exonuclease 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Exonuclease 1 |
| Short name: |
Anti-Exonuclease 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Exonuclease 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
28507 |
| Gene: |
EXD1 |
More about : EXD1 |
| Long gene name: |
domain containing 1 , exonuclease 3', -5' |
| Synonyms gene: |
EXDL1 |
| Synonyms gene name: |
domain-like 1 , exonuclease 3', -5' |
| Locus: |
15q15, 1 |
| Discovery year: |
2005-10-26 |
| GenBank acession: |
BC030628 |
| Entrez gene record: |
161829 |
| Pubmed identfication: |
12477932 |
| RefSeq identity: |
NM_152596 |
| Havana BLAST/BLAT: |
OTTHUMG00000130232 |